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Effect of bariatric surgery on plasma GDF15 in humans

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@article{6b13a8a91606440b9277b9406ace607a,
title = "Effect of bariatric surgery on plasma GDF15 in humans",
abstract = "Bariatric surgery results in marked body weight loss and improves type 2 diabetes in most patients with obesity. The growth differentiation factor 15 (GDF15) has recently emerged as a novel satiety factor. To begin to understand whether GDF15 is involved in mediating the effects of bariatric surgery on body weight and glycemia in humans, we measured plasma GDF15 in patients with obesity ( n = 25) and in patients with obesity and diabetes ( n = 22) before and after Roux-en-Y gastric bypass (RYGB) surgery. GDF15 was increased 1 wk after RYGB compared with before surgery (689 ± 45 vs. 487 ± 28 pg/ml, P < 0.001) and GDF15 remained elevated at 3 mo (554 ± 37 pg/ml, P < 0.05), at 1 yr (566 ± 37 pg/ml, P < 0.05), and at 2.5-4 yr (630 ± 50 pg/ml, P < 0.001) after RYGB surgery. Both age and insulin sensitivity correlated with GDF15 before the surgery ( r = 0.46, P < 0.0001 and r = 0.34, P < 0.001, respectively). These correlations disappeared at 2.5-4 yr following the surgery. Conversely, weight loss magnitude correlated with GDF15, measured 2.5-4 yr postsurgery ( r = 0.21, P < 0.0055). In summary, circulating GDF15 increases and correlates with body weight loss following RYGB surgery.",
keywords = "bariatric surgery, diabetes, GDF15, obesity, Roux-en-Y gastric bypass, Obesity, Bariatric surgery, Diabetes",
author = "Maximilian Kleinert and Bojsen-M{\o}ller, {Kirstine N} and J{\o}rgensen, {Nils B} and Svane, {Maria S} and Christoffer Martinussen and Bente Kiens and Wojtaszewski, {Jorgen F P} and Sten Madsbad and Richter, {Erik A} and Christoffer Clemmensen",
year = "2019",
month = "4",
day = "1",
doi = "10.1152/ajpendo.00010.2019",
language = "English",
volume = "316",
pages = "E615--E621",
journal = "American Journal of Physiology: Endocrinology and Metabolism",
issn = "0193-1849",
publisher = "American Physiological Society",
number = "4",

}

RIS

TY - JOUR

T1 - Effect of bariatric surgery on plasma GDF15 in humans

AU - Kleinert, Maximilian

AU - Bojsen-Møller, Kirstine N

AU - Jørgensen, Nils B

AU - Svane, Maria S

AU - Martinussen, Christoffer

AU - Kiens, Bente

AU - Wojtaszewski, Jorgen F P

AU - Madsbad, Sten

AU - Richter, Erik A

AU - Clemmensen, Christoffer

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Bariatric surgery results in marked body weight loss and improves type 2 diabetes in most patients with obesity. The growth differentiation factor 15 (GDF15) has recently emerged as a novel satiety factor. To begin to understand whether GDF15 is involved in mediating the effects of bariatric surgery on body weight and glycemia in humans, we measured plasma GDF15 in patients with obesity ( n = 25) and in patients with obesity and diabetes ( n = 22) before and after Roux-en-Y gastric bypass (RYGB) surgery. GDF15 was increased 1 wk after RYGB compared with before surgery (689 ± 45 vs. 487 ± 28 pg/ml, P < 0.001) and GDF15 remained elevated at 3 mo (554 ± 37 pg/ml, P < 0.05), at 1 yr (566 ± 37 pg/ml, P < 0.05), and at 2.5-4 yr (630 ± 50 pg/ml, P < 0.001) after RYGB surgery. Both age and insulin sensitivity correlated with GDF15 before the surgery ( r = 0.46, P < 0.0001 and r = 0.34, P < 0.001, respectively). These correlations disappeared at 2.5-4 yr following the surgery. Conversely, weight loss magnitude correlated with GDF15, measured 2.5-4 yr postsurgery ( r = 0.21, P < 0.0055). In summary, circulating GDF15 increases and correlates with body weight loss following RYGB surgery.

AB - Bariatric surgery results in marked body weight loss and improves type 2 diabetes in most patients with obesity. The growth differentiation factor 15 (GDF15) has recently emerged as a novel satiety factor. To begin to understand whether GDF15 is involved in mediating the effects of bariatric surgery on body weight and glycemia in humans, we measured plasma GDF15 in patients with obesity ( n = 25) and in patients with obesity and diabetes ( n = 22) before and after Roux-en-Y gastric bypass (RYGB) surgery. GDF15 was increased 1 wk after RYGB compared with before surgery (689 ± 45 vs. 487 ± 28 pg/ml, P < 0.001) and GDF15 remained elevated at 3 mo (554 ± 37 pg/ml, P < 0.05), at 1 yr (566 ± 37 pg/ml, P < 0.05), and at 2.5-4 yr (630 ± 50 pg/ml, P < 0.001) after RYGB surgery. Both age and insulin sensitivity correlated with GDF15 before the surgery ( r = 0.46, P < 0.0001 and r = 0.34, P < 0.001, respectively). These correlations disappeared at 2.5-4 yr following the surgery. Conversely, weight loss magnitude correlated with GDF15, measured 2.5-4 yr postsurgery ( r = 0.21, P < 0.0055). In summary, circulating GDF15 increases and correlates with body weight loss following RYGB surgery.

KW - bariatric surgery

KW - diabetes

KW - GDF15

KW - obesity

KW - Roux-en-Y gastric bypass

KW - Obesity

KW - Bariatric surgery

KW - Diabetes

UR - http://www.scopus.com/inward/record.url?scp=85064201470&partnerID=8YFLogxK

U2 - 10.1152/ajpendo.00010.2019

DO - 10.1152/ajpendo.00010.2019

M3 - Journal article

VL - 316

SP - E615-E621

JO - American Journal of Physiology: Endocrinology and Metabolism

JF - American Journal of Physiology: Endocrinology and Metabolism

SN - 0193-1849

IS - 4

ER -

ID: 56478607