TY - JOUR
T1 - Effect of aerobic exercise on physical performance in patients with Alzheimer's disease
AU - Sobol, Nanna Aue
AU - Hoffmann, Kristine
AU - Frederiksen, Kristian Steen
AU - Vogel, Asmus
AU - Vestergaard, Karsten
AU - Brændgaard, Hans
AU - Gottrup, Hanne
AU - Lolk, Annette
AU - Wermuth, Lene
AU - Jakobsen, Søren
AU - Laugesen, Lars
AU - Gergelyffy, Robert
AU - Høgh, Peter
AU - Bjerregaard, Eva
AU - Siersma, Volkert
AU - Andersen, Birgitte Bo
AU - Johannsen, Peter
AU - Waldemar, Gunhild
AU - Hasselbalch, Steen Gregers
AU - Beyer, Nina
N1 - Copyright © 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
PY - 2016/12
Y1 - 2016/12
N2 - INTRODUCTION: Knowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated the effect of aerobic exercise on physical performance in community-dwelling persons with mild Alzheimer's disease.METHODS: The single blinded multi-center RCT (ADEX) included 200 patients, median age 71 yrs (50-89). The intervention group received supervised moderate-to-high intensity aerobic exercise 1 hour × 3/week for 16 weeks. Assessments included cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy.RESULTS: Significant between-group differences in change from baseline (mean [95%CI]) favored the intervention group for cardiorespiratory fitness (4.0 [2.3-5.8] ml/kg/min, P <0.0001) and exercise self-efficacy (1.7 [0.5-2.8] points, P =0.004). Furthermore, an exercise attendance of ≥66.6% resulted in significant positive effects on single-task physical performance and dual-task performance.DISCUSSION: Aerobic exercise has the potential to improve cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy in community-dwelling patients with mild Alzheimer's disease.
AB - INTRODUCTION: Knowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated the effect of aerobic exercise on physical performance in community-dwelling persons with mild Alzheimer's disease.METHODS: The single blinded multi-center RCT (ADEX) included 200 patients, median age 71 yrs (50-89). The intervention group received supervised moderate-to-high intensity aerobic exercise 1 hour × 3/week for 16 weeks. Assessments included cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy.RESULTS: Significant between-group differences in change from baseline (mean [95%CI]) favored the intervention group for cardiorespiratory fitness (4.0 [2.3-5.8] ml/kg/min, P <0.0001) and exercise self-efficacy (1.7 [0.5-2.8] points, P =0.004). Furthermore, an exercise attendance of ≥66.6% resulted in significant positive effects on single-task physical performance and dual-task performance.DISCUSSION: Aerobic exercise has the potential to improve cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy in community-dwelling patients with mild Alzheimer's disease.
U2 - 10.1016/j.jalz.2016.05.004
DO - 10.1016/j.jalz.2016.05.004
M3 - Journal article
C2 - 27344641
SN - 1552-5260
VL - 12
SP - 1207
EP - 1215
JO - Alzheimer's & dementia : the journal of the Alzheimer's Association
JF - Alzheimer's & dementia : the journal of the Alzheimer's Association
IS - 12
ER -