Abstract
The effect of acute and long-term treatment with propranolol on cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen (CMRO2) has been studied in 8 young healthy volunteers. CBF was measured by 133Xe-inhalation and single photon emission computer tomography, and CMRO2 was calculated from the arterio-venous oxygen difference and CBF. Studies were done before and 1 h after i.v. injection of 5 mg propranolol and after three weeks on oral propranolol 80 mg/d for 1 week and 160 mg/d for 2 weeks. Cerebrovascular CO2 reactivity in terms of the A-V oxygen difference was tested on all three occasions during hypercapnia and hyperventilation. CBF, CMRO2 and cerebrovascular CO2 reactivity remained stable both after acute and after 3 weeks of treatment with propranolol.
| Original language | English |
|---|---|
| Journal | European Journal of Clinical Pharmacology |
| Volume | 39 |
| Issue number | 3 |
| Pages (from-to) | 295-7 |
| Number of pages | 3 |
| ISSN | 0031-6970 |
| DOIs | |
| Publication status | Published - 1990 |
| Externally published | Yes |
Keywords
- Administration, Oral
- Adult
- Blood Pressure/drug effects
- Cerebrovascular Circulation/drug effects
- Dose-Response Relationship, Drug
- Female
- Heart Rate/drug effects
- Humans
- Injections, Intravenous
- Male
- Oxygen/metabolism
- Propranolol/administration & dosage
- Tomography, Emission-Computed, Single-Photon
Fingerprint
Dive into the research topics of 'Effect of acute and prolonged treatment with propranolol on cerebral blood flow and cerebral oxygen metabolism in healthy volunteers'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS