Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Effect of 6 weeks of high-intensity one-legged cycling on functional sympatholysis and ATP signaling in patients with heart failure

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{395162ed52834b0a91aa42e1571d71c7,
title = "Effect of 6 weeks of high-intensity one-legged cycling on functional sympatholysis and ATP signaling in patients with heart failure",
abstract = "Breathlessness during daily activities is the primary symptom in patients with heart failure (HF). Poor correlation between the hemodynamic parameters of left ventricular performance and perceived symptoms suggests that other factors such as skeletal muscle function plays a role in determining exercise capacity. We investigated the effect of six weeks of high-intensity one-legged cycling (HIC; 8x4 at 90% one-legged cycling max) on: 1) the ability to override sympathetic vasoconstriction (arterial infusion of tyramine) during one-legged knee-extensor exercise (KEE); 2) vascular function (arterial infusion of ACh, SNP, tyramine and ATP); 3) exercise capacity in HF patients with reduced ejection fraction (n=8) compared with healthy individuals (n=6). Arterial tyramine infusion lowered leg blood flow and leg vascular conductance at rest and during KEE before the training intervention in both groups (P<0.05), but not during KEE after the training intervention. There was no difference between groups. The peak vasodilatory response to ATP was blunted in the HF patients. (P<0.05), whereas there was no difference in ACh- and SNP- induced vasodilation between HF patients and healthy individuals. ACh induced vasodilation increased in the HF patients after the training intervention (P<0.05). HIC improved aerobic capacity in both groups (P<0.05), whereas only the HF patients improved six min walking distance (P<0.05). These results suggest that exercise hyperemia and functional sympatholysis is not altered in HF patients, and that functional sympatholysis is improved with HIC in both HF patients and healthy individuals. Moreover, these results suggest that the peak vasodilatory response to ATP is blunted.",
keywords = "Journal Article",
author = "Munch, {Gregers Wibe} and Iepsen, {Ulrik Winning} and Ryrs{\o}, {Camilla Koch} and Rosenmeier, {Jaya Birgitte} and Pedersen, {Bente Klarlund} and Mortensen, {Stefan P}",
year = "2018",
doi = "10.1152/ajpheart.00379.2017",
language = "English",
volume = "314",
pages = "H616--H626",
journal = "American Journal of Physiology: Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "3",

}

RIS

TY - JOUR

T1 - Effect of 6 weeks of high-intensity one-legged cycling on functional sympatholysis and ATP signaling in patients with heart failure

AU - Munch, Gregers Wibe

AU - Iepsen, Ulrik Winning

AU - Ryrsø, Camilla Koch

AU - Rosenmeier, Jaya Birgitte

AU - Pedersen, Bente Klarlund

AU - Mortensen, Stefan P

PY - 2018

Y1 - 2018

N2 - Breathlessness during daily activities is the primary symptom in patients with heart failure (HF). Poor correlation between the hemodynamic parameters of left ventricular performance and perceived symptoms suggests that other factors such as skeletal muscle function plays a role in determining exercise capacity. We investigated the effect of six weeks of high-intensity one-legged cycling (HIC; 8x4 at 90% one-legged cycling max) on: 1) the ability to override sympathetic vasoconstriction (arterial infusion of tyramine) during one-legged knee-extensor exercise (KEE); 2) vascular function (arterial infusion of ACh, SNP, tyramine and ATP); 3) exercise capacity in HF patients with reduced ejection fraction (n=8) compared with healthy individuals (n=6). Arterial tyramine infusion lowered leg blood flow and leg vascular conductance at rest and during KEE before the training intervention in both groups (P<0.05), but not during KEE after the training intervention. There was no difference between groups. The peak vasodilatory response to ATP was blunted in the HF patients. (P<0.05), whereas there was no difference in ACh- and SNP- induced vasodilation between HF patients and healthy individuals. ACh induced vasodilation increased in the HF patients after the training intervention (P<0.05). HIC improved aerobic capacity in both groups (P<0.05), whereas only the HF patients improved six min walking distance (P<0.05). These results suggest that exercise hyperemia and functional sympatholysis is not altered in HF patients, and that functional sympatholysis is improved with HIC in both HF patients and healthy individuals. Moreover, these results suggest that the peak vasodilatory response to ATP is blunted.

AB - Breathlessness during daily activities is the primary symptom in patients with heart failure (HF). Poor correlation between the hemodynamic parameters of left ventricular performance and perceived symptoms suggests that other factors such as skeletal muscle function plays a role in determining exercise capacity. We investigated the effect of six weeks of high-intensity one-legged cycling (HIC; 8x4 at 90% one-legged cycling max) on: 1) the ability to override sympathetic vasoconstriction (arterial infusion of tyramine) during one-legged knee-extensor exercise (KEE); 2) vascular function (arterial infusion of ACh, SNP, tyramine and ATP); 3) exercise capacity in HF patients with reduced ejection fraction (n=8) compared with healthy individuals (n=6). Arterial tyramine infusion lowered leg blood flow and leg vascular conductance at rest and during KEE before the training intervention in both groups (P<0.05), but not during KEE after the training intervention. There was no difference between groups. The peak vasodilatory response to ATP was blunted in the HF patients. (P<0.05), whereas there was no difference in ACh- and SNP- induced vasodilation between HF patients and healthy individuals. ACh induced vasodilation increased in the HF patients after the training intervention (P<0.05). HIC improved aerobic capacity in both groups (P<0.05), whereas only the HF patients improved six min walking distance (P<0.05). These results suggest that exercise hyperemia and functional sympatholysis is not altered in HF patients, and that functional sympatholysis is improved with HIC in both HF patients and healthy individuals. Moreover, these results suggest that the peak vasodilatory response to ATP is blunted.

KW - Journal Article

U2 - 10.1152/ajpheart.00379.2017

DO - 10.1152/ajpheart.00379.2017

M3 - Journal article

C2 - 29167117

VL - 314

SP - H616-H626

JO - American Journal of Physiology: Heart and Circulatory Physiology

JF - American Journal of Physiology: Heart and Circulatory Physiology

SN - 0363-6135

IS - 3

ER -

ID: 52747249