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Effect of 6 weeks of high-intensity one-legged cycling on functional sympatholysis and ATP signaling in patients with heart failure

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Breathlessness during daily activities is the primary symptom in patients with heart failure (HF). Poor correlation between the hemodynamic parameters of left ventricular performance and perceived symptoms suggests that other factors such as skeletal muscle function plays a role in determining exercise capacity. We investigated the effect of six weeks of high-intensity one-legged cycling (HIC; 8x4 at 90% one-legged cycling max) on: 1) the ability to override sympathetic vasoconstriction (arterial infusion of tyramine) during one-legged knee-extensor exercise (KEE); 2) vascular function (arterial infusion of ACh, SNP, tyramine and ATP); 3) exercise capacity in HF patients with reduced ejection fraction (n=8) compared with healthy individuals (n=6). Arterial tyramine infusion lowered leg blood flow and leg vascular conductance at rest and during KEE before the training intervention in both groups (P<0.05), but not during KEE after the training intervention. There was no difference between groups. The peak vasodilatory response to ATP was blunted in the HF patients. (P<0.05), whereas there was no difference in ACh- and SNP- induced vasodilation between HF patients and healthy individuals. ACh induced vasodilation increased in the HF patients after the training intervention (P<0.05). HIC improved aerobic capacity in both groups (P<0.05), whereas only the HF patients improved six min walking distance (P<0.05). These results suggest that exercise hyperemia and functional sympatholysis is not altered in HF patients, and that functional sympatholysis is improved with HIC in both HF patients and healthy individuals. Moreover, these results suggest that the peak vasodilatory response to ATP is blunted.

Original languageEnglish
JournalAmerican Journal of Physiology: Heart and Circulatory Physiology
Volume314
Issue number3
Pages (from-to)H616-H626
ISSN0363-6135
DOIs
Publication statusPublished - 2018

    Research areas

  • Journal Article

ID: 52747249