Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

EEG with extreme delta brush in young female with methotrexate neurotoxicity supports NMDA receptor involvement

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Decline in severe spastic cerebral palsy at term in Denmark 1999-2007

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. SLC35A2-related congenital disorder of glycosylation: Defining the phenotype

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Neuromodulation for chronic pain and double incontinence in children

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Classmates motivate childhood cancer patients to participate in physical activity during treatment: A qualitative study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Infections seem to be more frequent before onset of pediatric multiple sclerosis: A Danish nationwide nested case-control study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Psychotropic Medication Use in Parents of Children Diagnosed With Cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Sperm DNA Integrity is Unaffected by Thiopurine Treatment in Men With Inflammatory Bowel Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Sub-acute neurotoxicity is a well-known complication to high-dose and intrathecal methotrexate (MTX) treatment of children with leukemia. Symptoms can be treated safely by dextromethorphan, a non-competitive antagonist to N-methyl-D-aspartic acid receptor (NMDAR). In a female with subacute MTX neurotoxicity, we observed an electroencephalographic (EEG) with extreme delta brush. Extreme delta brush is an EEG pattern previously described in patients with NMDAR autoimmune encephalitis. The observations suggest that the mechanism of this neurotoxicity may be mediated by the NMDAR. Furthermore, extreme EEG delta brush should suggest a diagnosis of MTX associated subacute neurotoxicity.

Original languageEnglish
JournalEuropean journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Volume21
Issue number5
Pages (from-to)795-797
Number of pages3
ISSN1090-3798
DOIs
Publication statusPublished - Sep 2017

    Research areas

  • Journal Article

ID: 52673611