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The Capital Region of Denmark - a part of Copenhagen University Hospital
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EEG with extreme delta brush in young female with methotrexate neurotoxicity supports NMDA receptor involvement

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Sub-acute neurotoxicity is a well-known complication to high-dose and intrathecal methotrexate (MTX) treatment of children with leukemia. Symptoms can be treated safely by dextromethorphan, a non-competitive antagonist to N-methyl-D-aspartic acid receptor (NMDAR). In a female with subacute MTX neurotoxicity, we observed an electroencephalographic (EEG) with extreme delta brush. Extreme delta brush is an EEG pattern previously described in patients with NMDAR autoimmune encephalitis. The observations suggest that the mechanism of this neurotoxicity may be mediated by the NMDAR. Furthermore, extreme EEG delta brush should suggest a diagnosis of MTX associated subacute neurotoxicity.

Original languageEnglish
JournalEuropean journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Volume21
Issue number5
Pages (from-to)795-797
Number of pages3
ISSN1090-3798
DOIs
Publication statusPublished - Sep 2017

    Research areas

  • Journal Article

ID: 52673611