Educational attainment does not influence brain aging

Lars Nyberg; Fredrik Magnussen; Anders Lundquist; William Baaré; David Bartrés-Faz; Lars Bertram; C J Boraxbekk; Andreas M Brandmaier; Christian A Drevon; Klaus Ebmeier; Paolo Ghisletta; Richard N Henson; Carme Junqué; Rogier Kievit; Maike Kleemeyer; Ethan Knights; Simone Kühn; Ulman Lindenberger; Brenda W J H Penninx; Sara Pudas; Øystein Sørensen; Lídia Vaqué-Alcázar; Kristine B Walhovd; Anders M Fjell

doi:10.1073/pnas.2101644118

Educational attainment does not influence brain aging

Lars Nyberg, Fredrik Magnussen, Anders Lundquist, William Baaré, David Bartrés-Faz, Lars Bertram, C J Boraxbekk, Andreas M Brandmaier, Christian A Drevon, Klaus Ebmeier, Paolo Ghisletta, Richard N Henson, Carme Junqué, Rogier Kievit, Maike Kleemeyer, Ethan Knights, Simone Kühn, Ulman Lindenberger, Brenda W J H Penninx, Sara PudasØystein Sørensen, Lídia Vaqué-Alcázar, Kristine B Walhovd, Anders M Fjell

72 Citations (Scopus)

Abstract

Education has been related to various advantageous lifetime outcomes. Here, using longitudinal structural MRI data (4,422 observations), we tested the influential hypothesis that higher education translates into slower rates of brain aging. Cross-sectionally, education was modestly associated with regional cortical volume. However, despite marked mean atrophy in the cortex and hippocampus, education did not influence rates of change. The results were replicated across two independent samples. Our findings challenge the view that higher education slows brain aging.

Original language	English
Article number	2101644118
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	118
Issue number	18
Pages (from-to)	1-3
Number of pages	3
ISSN	0027-8424
DOIs	https://doi.org/10.1073/pnas.2101644118
Publication status	Published - 4 May 2021

Keywords

Aging
Cerebral cortex
Education
Hippocampus
Reserve
Humans
Middle Aged
Male
Aging/physiology
Brain/diagnostic imaging
Magnetic Resonance Imaging
Cerebral Cortex/diagnostic imaging
Hippocampus/diagnostic imaging
Female
Aged

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Nyberg, L., Magnussen, F., Lundquist, A., Baaré, W., Bartrés-Faz, D., Bertram, L., Boraxbekk, C. J., Brandmaier, A. M., Drevon, C. A., Ebmeier, K., Ghisletta, P., Henson, R. N., Junqué, C., Kievit, R., Kleemeyer, M., Knights, E., Kühn, S., Lindenberger, U., Penninx, B. W. J. H., ... Fjell, A. M. (2021). Educational attainment does not influence brain aging. Proceedings of the National Academy of Sciences of the United States of America, 118(18), 1-3. Article 2101644118. https://doi.org/10.1073/pnas.2101644118

Nyberg, L, Magnussen, F, Lundquist, A, Baaré, W, Bartrés-Faz, D, Bertram, L, Boraxbekk, CJ, Brandmaier, AM, Drevon, CA, Ebmeier, K, Ghisletta, P, Henson, RN, Junqué, C, Kievit, R, Kleemeyer, M, Knights, E, Kühn, S, Lindenberger, U, Penninx, BWJH, Pudas, S, Sørensen, Ø, Vaqué-Alcázar, L, Walhovd, KB & Fjell, AM 2021, 'Educational attainment does not influence brain aging', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 18, 2101644118, pp. 1-3. https://doi.org/10.1073/pnas.2101644118

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title = "Educational attainment does not influence brain aging",

abstract = "Education has been related to various advantageous lifetime outcomes. Here, using longitudinal structural MRI data (4,422 observations), we tested the influential hypothesis that higher education translates into slower rates of brain aging. Cross-sectionally, education was modestly associated with regional cortical volume. However, despite marked mean atrophy in the cortex and hippocampus, education did not influence rates of change. The results were replicated across two independent samples. Our findings challenge the view that higher education slows brain aging.",

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AU - Brandmaier, Andreas M

AU - Drevon, Christian A

AU - Ebmeier, Klaus

AU - Ghisletta, Paolo

AU - Henson, Richard N

AU - Junqué, Carme

AU - Kievit, Rogier

AU - Kleemeyer, Maike

AU - Knights, Ethan

AU - Kühn, Simone

AU - Lindenberger, Ulman

AU - Penninx, Brenda W J H

AU - Pudas, Sara

AU - Sørensen, Øystein

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AU - Walhovd, Kristine B

AU - Fjell, Anders M

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Educational attainment does not influence brain aging

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