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EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?

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Arendrup, Frederic Schrøder ; Mazaud-Guittot, Severine ; Jégou, Bernard ; Kristensen, David Møbjerg. / EDC IMPACT : Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?. In: Endocrine Connections. 2018 ; Vol. 7, No. 1. pp. 149-158.

Bibtex

@article{f5b8112f486a49df9590c5b02f4ae22e,
title = "EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?",
abstract = "Concern has been raised over chemical-induced disruption of ovary development during fetal life resulting in long-lasting consequences only manifesting themselves much later during adulthood. A growing body of evidence suggests that prenatal exposure to the mild analgesic acetaminophen/paracetamol can cause such a scenario. Therefore, in this review, we discuss three recent reports that collectively indicate that prenatal exposure in a period of 13.5 days post coitum in both rats and mouse can result in reduced female reproductive health. The combined data show that the exposure results in the reduction of primordial follicles, irregular menstrual cycle, premature absence of corpus luteum, as well as reduced fertility, resembling premature ovarian insufficiency syndrome in humans that is linked to premature menopause. This could especially affect the Western parts of the world, where the age for childbirth is continuously being increased and acetaminophen is recommended during pregnancy for pain and fever. We therefore highlight an urgent need for more studies to verify these data including both experimental and epidemiological approaches.",
author = "Arendrup, {Frederic Schr{\o}der} and Severine Mazaud-Guittot and Bernard J{\'e}gou and Kristensen, {David M{\o}bjerg}",
note = "{\circledC} 2018 The authors.",
year = "2018",
doi = "10.1530/EC-17-0298",
language = "English",
volume = "7",
pages = "149--158",
journal = "Endocrine Connections",
issn = "2049-3614",
publisher = "BioScientifica Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - EDC IMPACT

T2 - Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?

AU - Arendrup, Frederic Schrøder

AU - Mazaud-Guittot, Severine

AU - Jégou, Bernard

AU - Kristensen, David Møbjerg

N1 - © 2018 The authors.

PY - 2018

Y1 - 2018

N2 - Concern has been raised over chemical-induced disruption of ovary development during fetal life resulting in long-lasting consequences only manifesting themselves much later during adulthood. A growing body of evidence suggests that prenatal exposure to the mild analgesic acetaminophen/paracetamol can cause such a scenario. Therefore, in this review, we discuss three recent reports that collectively indicate that prenatal exposure in a period of 13.5 days post coitum in both rats and mouse can result in reduced female reproductive health. The combined data show that the exposure results in the reduction of primordial follicles, irregular menstrual cycle, premature absence of corpus luteum, as well as reduced fertility, resembling premature ovarian insufficiency syndrome in humans that is linked to premature menopause. This could especially affect the Western parts of the world, where the age for childbirth is continuously being increased and acetaminophen is recommended during pregnancy for pain and fever. We therefore highlight an urgent need for more studies to verify these data including both experimental and epidemiological approaches.

AB - Concern has been raised over chemical-induced disruption of ovary development during fetal life resulting in long-lasting consequences only manifesting themselves much later during adulthood. A growing body of evidence suggests that prenatal exposure to the mild analgesic acetaminophen/paracetamol can cause such a scenario. Therefore, in this review, we discuss three recent reports that collectively indicate that prenatal exposure in a period of 13.5 days post coitum in both rats and mouse can result in reduced female reproductive health. The combined data show that the exposure results in the reduction of primordial follicles, irregular menstrual cycle, premature absence of corpus luteum, as well as reduced fertility, resembling premature ovarian insufficiency syndrome in humans that is linked to premature menopause. This could especially affect the Western parts of the world, where the age for childbirth is continuously being increased and acetaminophen is recommended during pregnancy for pain and fever. We therefore highlight an urgent need for more studies to verify these data including both experimental and epidemiological approaches.

U2 - 10.1530/EC-17-0298

DO - 10.1530/EC-17-0298

M3 - Journal article

VL - 7

SP - 149

EP - 158

JO - Endocrine Connections

JF - Endocrine Connections

SN - 2049-3614

IS - 1

ER -

ID: 55229591