Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Early risk stratification using Rubidium-82 positron emission tomography in STEMI patients

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Heart failure patients with prediabetes and newly diagnosed diabetes display abnormalities in myocardial metabolism

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Respiratory gating in cardiac PET: Effects of adenosine and dipyridamole

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Perfusion imaging using rubidium-82 ((82)Rb) PET in rats with myocardial infarction: First small animal cardiac (82)Rb-PET

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Near-infrared fluorescence imaging improves the nodal yield in neck dissection in oral cavity cancer - A randomized study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A More COMPLETE Picture of Revascularization in STEMI

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Polygenic predisposition to breast cancer and the risk of coronary artery disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Unreported exclusion and sampling bias in interpretation of randomized controlled trials in patients with STEMI

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Assessment of infarct size after myocardial infarction is predictive of subsequent morphological changes and clinical outcome. This study aimed to assess subacute post-intervention Rubidium-82 (82Rb)-PET imaging in predicting left ventricle ejection fraction, regional wall motion, and final infarct size by CMR at 3-months after STEMI.

METHODS: STEMI patients undergoing percutaneous coronary intervention were included prospectively. Rest-only 82Rb-PET perfusion imaging was performed at median 36 hours [IQR: 22 to 50] after the treatment. The extent of hypoperfusion and absolute blood flow (mL·min·g) were estimated on a global and a 17-segment model with dedicated software. At 3-months follow-up patients completed the CMR functional and late gadolinium enhancement imaging.

RESULTS: 42 patients were included, but only 35 had follow-up CMR and constituted the study population. Absolute blood flow was significantly lower in the infarct-related territory compared to remote myocardium, P < .005. Extent of hypoperfusion correlated with final infarct size, r = 0.58, P < .001, while blood flow correlated with ejection fraction, r = 0.41, P < .05. In linear mixed models, higher subacute absolute blood flow (β = 4.6, confidence interval [3.5; 5.2], P < .001, R 2 = 0.67) was associated with greater wall motion. Segmental extent of subacute hypoperfusion (β = 0.43 [0.38; 0.49], P < .001, R 2 = 0.58) was associated with the degree of late gadolinium enhancement at 3-months.

CONCLUSIONS: Subacute rest-only 82Rb-PET is feasible following STEMI and seems predictive of myocardial function and infarct size at 3-months.

Original languageEnglish
JournalJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Pages (from-to)epub
ISSN1071-3581
DOIs
Publication statusE-pub ahead of print - 2019

    Research areas

  • Journal Article

ID: 52686703