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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Early life body size, growth and risks of systemic lupus erythematosus - A large Danish observational cohort study

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  1. Intake of n-3 LCPUFA and trans-fatty acids is unrelated to development in body mass index and body fat among children

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  2. Doppler ultrasound predicts successful discontinuation of biological DMARDs in rheumatoid arthritis patients in clinical remission

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  3. Instrumental variable analysis using offspring BMI in childhood as an indicator of parental BMI in relation to mortality

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OBJECTIVES: Adult obesity may increase the risks of systemic lupus erythematosus (SLE), and there are genetic links between adult height and SLE. Thus, it is plausible that size earlier in life may be important in the aetiology of SLE as well. We investigated whether birthweight, childhood body mass index (BMI; [kg/m2]), height and growth are associated with risks of adult SLE.

METHODS: The study included 346,627 children from the Copenhagen School Health Records Register, born 1930-1996 with measured weights and heights from 7-13 years. Birthweight information was available from 1936. Linkages were made to the Danish National Patient Register for information on registrations of SLE. During follow-up, 435 individuals (366 women) were registered with SLE. Cox proportional hazards regressions were performed to estimate hazard ratios (HR) and 95% confidence intervals (CI).

RESULTS: No differences by sex were detected in any of the associations. Birthweight was not associated with SLE risks. Childhood BMI and height were positively and linearly associated with SLE risks. For BMI at age 7, the HR was 1.11 (95% CI: 1.01-1.23) per z-score. For height at age 7, the HR was 1.13 (95% CI: 1.02-1.24) per z-score. The estimates were similar in magnitude across all childhood ages for BMI and height. There were limited indications that change in BMI or growth in height during childhood influence the risks of SLE in adulthood.

CONCLUSIONS: Childhood body size is associated with risks of adult SLE, which supports the hypothesis that early life factors are important in SLE aetiology.

Original languageEnglish
JournalSeminars in Arthritis and Rheumatism
Volume50
Issue number6
Pages (from-to)1507-1512
Number of pages6
ISSN0049-0172
DOIs
Publication statusPublished - Dec 2020

    Research areas

  • Birthweight, Body weights and measures, Child, Growth and development, Obesity, Systemic lupus erythematosus

ID: 59633090