Early- and late-onset posttransplant lymphoproliferative disorders among adult kidney and liver transplant recipients

3 Citations (Scopus)

Abstract

OBJECTIVES: Posttransplant lymphoproliferative disorder (PTLD) in solid organ transplant recipients has a high mortality and may present early (<2 years) or late (≥2 years) posttransplantation. We investigated the clinical characteristics of early and late PTLD among kidney and liver transplant recipients.

METHODS: Recipients, transplanted at Rigshospitalet, with PTLD development as adults from January 2010 to August 2020, were included. Clinical characteristics, laboratory parameters, and pathology of early and late PTLD were compared.

RESULTS: Thirty-one PTLD cases were detected where 10 (32%) were early and 21 (68%) were late PTLD. EBV DNA in plasma was detected in 78% versus 28% in early and late PTLD (p = .037). None of the recipients with early PTLD and nine recipients with late PTLD (47%) had Ann Arbor stage IV at the time of their diagnosis (p = .006). Cyclophosphamid-Hydroxyrubicin-Oncovin-Prednisolon was used for treatment in 10 (48%) recipients with late PTLD (p = 0.032) only. There was no difference in mortality between the two groups.

CONCLUSIONS: Recipients with late PTLD had a lower prevalence of detectable EBV DNA in plasma, were diagnosed with more advanced disease, and were more frequently treated with chemotherapy compared to recipients with early PTLD.

Original languageEnglish
JournalEuropean Journal of Haematology
Volume109
Issue number4
Pages (from-to)343-350
Number of pages8
ISSN0902-4441
DOIs
Publication statusPublished - Oct 2022

Keywords

  • Adult
  • Epstein-Barr Virus Infections/complications
  • Humans
  • Incidence
  • Kidney
  • Liver Transplantation/adverse effects
  • Lymphoproliferative Disorders/diagnosis
  • Retrospective Studies
  • Risk Factors
  • Transplant Recipients
  • posttransplant lymphoproliferative disorder
  • kidney transplantation
  • solid organ transplantation
  • liver transplantation

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