Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Dysregulated Lipid Metabolism Precedes Onset of Psychosis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Meta-analysis of the Glial Marker TSPO in Psychosis Revisited: Reconciling Inconclusive Findings of Patient-Control Differences

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Pharmacogenetic genotype and phenotype frequencies in a large Danish population-based case-cohort sample

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Gestational age-dependent development of the neonatal metabolome

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Co-occurring hydrocephalus in autism spectrum disorder: a Danish population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • EU-GEI High Risk Study Group
View graph of relations

BACKGROUND: A key clinical challenge in the management of individuals at clinical high risk for psychosis (CHR) is that it is difficult to predict their future clinical outcomes. Here, we investigated if the levels of circulating molecular lipids are related to adverse clinical outcomes in this group.

METHODS: Serum lipidomic analysis was performed in 263 CHR individuals and 51 healthy control subjects, who were then clinically monitored for up to 5 years. Machine learning was used to identify lipid profiles that discriminated between CHR and control subjects, and between subgroups of CHR subjects with distinct clinical outcomes.

RESULTS: At baseline, compared with control subjects, CHR subjects (independent of outcome) had higher levels of triacylglycerols with a low acyl carbon number and a double bond count, as well as higher levels of lipids in general. CHR subjects who subsequently developed psychosis (n = 50) were distinguished from those that did not (n = 213) on the basis of lipid profile at baseline using a model with an area under the receiver operating curve of 0.81 (95% confidence interval = 0.69-0.93). CHR subjects who became psychotic had lower levels of ether phospholipids than CHR individuals who did not (p < .01).

CONCLUSIONS: Collectively, these data suggest that lipidomic abnormalities predate the onset of psychosis and that blood lipidomic measures may be useful in predicting which CHR individuals are most likely to develop psychosis.

Original languageEnglish
JournalBiological Psychiatry
Volume89
Issue number3
Pages (from-to)288-297
Number of pages10
ISSN0006-3223
DOIs
Publication statusPublished - 1 Feb 2021

ID: 61716633