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Dynamic interplay between the collagen scaffold and tumor evolution

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Egeblad, Mikala ; Rasch, Morten G ; Weaver, Valerie M. / Dynamic interplay between the collagen scaffold and tumor evolution. In: Current Opinion in Cell Biology. 2010 ; Vol. 22, No. 5. pp. 697-706.

Bibtex

@article{92b5ce5b69ca43c5b9a49a54806554d1,
title = "Dynamic interplay between the collagen scaffold and tumor evolution",
abstract = "The extracellular matrix (ECM) is a key regulator of cell and tissue function. Traditionally, the ECM has been thought of primarily as a physical scaffold that binds cells and tissues together. However, the ECM also elicits biochemical and biophysical signaling. Controlled proteolysis and remodeling of the ECM network regulate tissue tension, generate pathways for migration, and release ECM protein fragments to direct normal developmental processes such as branching morphogenesis. Collagens are major components of the ECM of which basement membrane type IV and interstitial matrix type I are the most prevalent. Here we discuss how abnormal expression, proteolysis and structure of these collagens influence cellular functions to elicit multiple effects on tumors, including proliferation, initiation, invasion, metastasis, and therapy response.",
author = "Mikala Egeblad and Rasch, {Morten G} and Weaver, {Valerie M}",
note = "Copyright {\circledC} 2010 Elsevier Ltd. All rights reserved.",
year = "2010",
month = "10",
day = "1",
doi = "10.1016/j.ceb.2010.08.015",
language = "English",
volume = "22",
pages = "697--706",
journal = "Current Biology",
issn = "0955-0674",
publisher = "Elsevier Ltd. Current Opinion Journals",
number = "5",

}

RIS

TY - JOUR

T1 - Dynamic interplay between the collagen scaffold and tumor evolution

AU - Egeblad, Mikala

AU - Rasch, Morten G

AU - Weaver, Valerie M

N1 - Copyright © 2010 Elsevier Ltd. All rights reserved.

PY - 2010/10/1

Y1 - 2010/10/1

N2 - The extracellular matrix (ECM) is a key regulator of cell and tissue function. Traditionally, the ECM has been thought of primarily as a physical scaffold that binds cells and tissues together. However, the ECM also elicits biochemical and biophysical signaling. Controlled proteolysis and remodeling of the ECM network regulate tissue tension, generate pathways for migration, and release ECM protein fragments to direct normal developmental processes such as branching morphogenesis. Collagens are major components of the ECM of which basement membrane type IV and interstitial matrix type I are the most prevalent. Here we discuss how abnormal expression, proteolysis and structure of these collagens influence cellular functions to elicit multiple effects on tumors, including proliferation, initiation, invasion, metastasis, and therapy response.

AB - The extracellular matrix (ECM) is a key regulator of cell and tissue function. Traditionally, the ECM has been thought of primarily as a physical scaffold that binds cells and tissues together. However, the ECM also elicits biochemical and biophysical signaling. Controlled proteolysis and remodeling of the ECM network regulate tissue tension, generate pathways for migration, and release ECM protein fragments to direct normal developmental processes such as branching morphogenesis. Collagens are major components of the ECM of which basement membrane type IV and interstitial matrix type I are the most prevalent. Here we discuss how abnormal expression, proteolysis and structure of these collagens influence cellular functions to elicit multiple effects on tumors, including proliferation, initiation, invasion, metastasis, and therapy response.

U2 - 10.1016/j.ceb.2010.08.015

DO - 10.1016/j.ceb.2010.08.015

M3 - Journal article

VL - 22

SP - 697

EP - 706

JO - Current Biology

JF - Current Biology

SN - 0955-0674

IS - 5

ER -

ID: 32221181