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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

Research output: Contribution to journalJournal articleResearchpeer-review

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  • Lisa Vermunt
  • Sietske A M Sikkes
  • Ardo van den Hout
  • Ron Handels
  • Isabelle Bos
  • Wiesje M van der Flier
  • Silke Kern
  • Pierre-Jean Ousset
  • Paul Maruff
  • Ingmar Skoog
  • Frans R J Verhey
  • Yvonne Freund-Levi
  • Magda Tsolaki
  • Åsa K Wallin
  • Marcel Olde Rikkert
  • Hilkka Soininen
  • Luisa Spiru
  • Henrik Zetterberg
  • Kaj Blennow
  • Philip Scheltens
  • Graciela Muniz-Terrera
  • Pieter Jelle Visser
  • Alzheimer Disease Neuroimaging Initiative
  • Gunhild Waldemar (Member of study group)
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INTRODUCTION: We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration.

METHODS: We performed multistate modeling in a combined sample of 6 cohorts (n = 3268) with death as the end stage and estimated the preclinical, prodromal, and dementia stage duration.

RESULTS: The overall AD duration varied between 24 years (age 60) and 15 years (age 80). For individuals presenting with preclinical AD, age 70, the estimated preclinical AD duration was 10 years, prodromal AD 4 years, and dementia 6 years. Male sex, clinical setting, APOE ε4 allele carriership, and abnormal cerebrospinal fluid tau were associated with a shorter duration, and these effects depended on disease stage.

DISCUSSION: Estimates of AD disease duration become more accurate if age, sex, setting, APOE, and cerebrospinal fluid tau are taken into account. This will be relevant for clinical practice and trial design.

Original languageEnglish
JournalAlzheimer's & dementia : the journal of the Alzheimer's Association
Volume15
Issue number7
Pages (from-to)888-898
Number of pages11
ISSN1552-5260
DOIs
Publication statusPublished - Jul 2019

ID: 59465563