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DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study

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Harvard

Jönsson, EG, Saetre, P, Vares, M, Andreou, D, Larsson, K, Timm, S, Rasmussen, HB, Djurovic, S, Melle, I, Andreassen, OA, Agartz, I, Werge, T, Hall, H & Terenius, L 2009, 'DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study' Neuropsychobiology, vol. 59, no. 3, pp. 142-50. https://doi.org/10.1159/000218076

APA

Jönsson, E. G., Saetre, P., Vares, M., Andreou, D., Larsson, K., Timm, S., ... Terenius, L. (2009). DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. Neuropsychobiology, 59(3), 142-50. https://doi.org/10.1159/000218076

CBE

Jönsson EG, Saetre P, Vares M, Andreou D, Larsson K, Timm S, Rasmussen HB, Djurovic S, Melle I, Andreassen OA, Agartz I, Werge T, Hall H, Terenius L. 2009. DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. Neuropsychobiology. 59(3):142-50. https://doi.org/10.1159/000218076

MLA

Vancouver

Author

Jönsson, Erik G ; Saetre, Peter ; Vares, Maria ; Andreou, Dimitrios ; Larsson, Kristina ; Timm, Sally ; Rasmussen, Henrik B ; Djurovic, Srdjan ; Melle, Ingrid ; Andreassen, Ole A ; Agartz, Ingrid ; Werge, Thomas ; Hall, Håkan ; Terenius, Lars. / DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. In: Neuropsychobiology. 2009 ; Vol. 59, No. 3. pp. 142-50.

Bibtex

@article{3fa42ff06c8111dfa4b2000ea68e967b,
title = "DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study",
abstract = "BACKGROUND: Several studies of the dystrobrevin-binding protein 1 gene (DTNBP1), neuregulin 1 (NRG1), D-amino-acid oxidase (DAO), DAO activator (DAOA, G72), and metabotropic glutamate receptor 3 (GRM3) genes have suggested an association between variants of these genes and schizophrenia. METHODS: In a replication attempt, single-nucleotide polymorphisms of the DTNBP1, NRG1, DAO, DAOA, and GRM3 genes were analyzed in three independent Scandinavian schizophrenia case-control samples. RESULTS: One DTNBP1 and three GRM3 single-nucleotide polymorphisms showed nominal significant associations to the disease. However, after correction for multiple testing, there were no statistically significant allele, genotype or haplotype case-control differences. CONCLUSIONS: The present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia. Additional studies and meta-analyses are warranted to shed further light on these relationships.",
author = "J{\"o}nsson, {Erik G} and Peter Saetre and Maria Vares and Dimitrios Andreou and Kristina Larsson and Sally Timm and Rasmussen, {Henrik B} and Srdjan Djurovic and Ingrid Melle and Andreassen, {Ole A} and Ingrid Agartz and Thomas Werge and H{\aa}kan Hall and Lars Terenius",
note = "Keywords: Adult; Alleles; Carrier Proteins; Case-Control Studies; D-Amino-Acid Oxidase; DNA Mutational Analysis; Female; Gene Frequency; Genome-Wide Association Study; Genotype; Haplotypes; Humans; Logistic Models; Male; Middle Aged; Nerve Tissue Proteins; Odds Ratio; Polymorphism, Single Nucleotide; Receptors, Metabotropic Glutamate; Schizophrenia",
year = "2009",
doi = "10.1159/000218076",
language = "English",
volume = "59",
pages = "142--50",
journal = "Neuropsychobiology",
issn = "0302-282X",
publisher = "S./Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study

AU - Jönsson, Erik G

AU - Saetre, Peter

AU - Vares, Maria

AU - Andreou, Dimitrios

AU - Larsson, Kristina

AU - Timm, Sally

AU - Rasmussen, Henrik B

AU - Djurovic, Srdjan

AU - Melle, Ingrid

AU - Andreassen, Ole A

AU - Agartz, Ingrid

AU - Werge, Thomas

AU - Hall, Håkan

AU - Terenius, Lars

N1 - Keywords: Adult; Alleles; Carrier Proteins; Case-Control Studies; D-Amino-Acid Oxidase; DNA Mutational Analysis; Female; Gene Frequency; Genome-Wide Association Study; Genotype; Haplotypes; Humans; Logistic Models; Male; Middle Aged; Nerve Tissue Proteins; Odds Ratio; Polymorphism, Single Nucleotide; Receptors, Metabotropic Glutamate; Schizophrenia

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Several studies of the dystrobrevin-binding protein 1 gene (DTNBP1), neuregulin 1 (NRG1), D-amino-acid oxidase (DAO), DAO activator (DAOA, G72), and metabotropic glutamate receptor 3 (GRM3) genes have suggested an association between variants of these genes and schizophrenia. METHODS: In a replication attempt, single-nucleotide polymorphisms of the DTNBP1, NRG1, DAO, DAOA, and GRM3 genes were analyzed in three independent Scandinavian schizophrenia case-control samples. RESULTS: One DTNBP1 and three GRM3 single-nucleotide polymorphisms showed nominal significant associations to the disease. However, after correction for multiple testing, there were no statistically significant allele, genotype or haplotype case-control differences. CONCLUSIONS: The present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia. Additional studies and meta-analyses are warranted to shed further light on these relationships.

AB - BACKGROUND: Several studies of the dystrobrevin-binding protein 1 gene (DTNBP1), neuregulin 1 (NRG1), D-amino-acid oxidase (DAO), DAO activator (DAOA, G72), and metabotropic glutamate receptor 3 (GRM3) genes have suggested an association between variants of these genes and schizophrenia. METHODS: In a replication attempt, single-nucleotide polymorphisms of the DTNBP1, NRG1, DAO, DAOA, and GRM3 genes were analyzed in three independent Scandinavian schizophrenia case-control samples. RESULTS: One DTNBP1 and three GRM3 single-nucleotide polymorphisms showed nominal significant associations to the disease. However, after correction for multiple testing, there were no statistically significant allele, genotype or haplotype case-control differences. CONCLUSIONS: The present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia. Additional studies and meta-analyses are warranted to shed further light on these relationships.

U2 - 10.1159/000218076

DO - 10.1159/000218076

M3 - Journal article

VL - 59

SP - 142

EP - 150

JO - Neuropsychobiology

JF - Neuropsychobiology

SN - 0302-282X

IS - 3

ER -

ID: 172009