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DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study

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BACKGROUND: Several studies of the dystrobrevin-binding protein 1 gene (DTNBP1), neuregulin 1 (NRG1), D-amino-acid oxidase (DAO), DAO activator (DAOA, G72), and metabotropic glutamate receptor 3 (GRM3) genes have suggested an association between variants of these genes and schizophrenia. METHODS: In a replication attempt, single-nucleotide polymorphisms of the DTNBP1, NRG1, DAO, DAOA, and GRM3 genes were analyzed in three independent Scandinavian schizophrenia case-control samples. RESULTS: One DTNBP1 and three GRM3 single-nucleotide polymorphisms showed nominal significant associations to the disease. However, after correction for multiple testing, there were no statistically significant allele, genotype or haplotype case-control differences. CONCLUSIONS: The present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia. Additional studies and meta-analyses are warranted to shed further light on these relationships.
Original languageEnglish
JournalNeuropsychobiology
Volume59
Issue number3
Pages (from-to)142-50
Number of pages8
ISSN0302-282X
DOIs
Publication statusPublished - 2009

Bibliographical note

Keywords: Adult; Alleles; Carrier Proteins; Case-Control Studies; D-Amino-Acid Oxidase; DNA Mutational Analysis; Female; Gene Frequency; Genome-Wide Association Study; Genotype; Haplotypes; Humans; Logistic Models; Male; Middle Aged; Nerve Tissue Proteins; Odds Ratio; Polymorphism, Single Nucleotide; Receptors, Metabotropic Glutamate; Schizophrenia

ID: 172009