Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Drug-drug interactions between vitamin K antagonists and statins: a systematic review

Research output: Contribution to journalReviewResearchpeer-review

  1. Pharmacoepidemiological methods for computing the duration of pharmacological prescriptions using secondary data sources

    Research output: Contribution to journalReviewResearchpeer-review

  2. The Danish model for the quick and safe implementation of infliximab and etanercept biosimilars

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Use of prescription drugs in the older adult population-a nationwide pharmacoepidemiological study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Quality assessment of structure and language elements of written responses given by seven Scandinavian drug information centres

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Decreased plasma lipid levels in a statin-free Danish primary health care cohort between 2001 and 2018

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Influence of educational level on test and treatment for incident hypothyroidism

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Antimycotic treatment of oral candidiasis in warfarin users

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Vitamin D levels and the risk of prostate cancer and prostate cancer mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Drug-drug interaction between warfarin and statins: A Danish cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE: Concomitant use of vitamin K antagonists (VKA) and statins is frequent in cardiovascular patients. However, clinical guidelines on this drug combination are divergent. Therefore, we performed a systematic review to evaluate the effect of statin initiation on coagulation among VKA users.

METHODS: Following the PRISMA guidelines, we applied two broad search strategies for the drug interaction between VKA and statins in both Embase and Pubmed; 8623 unique hits were obtained. In the final sample, eight studies were included.

RESULTS: The most frequently used VKA in the studies was warfarin, while simvastatin was the most commonly initiated statin. All included studies showed a minor increase in the anticoagulant effect of VKA following statin initiation during VKA treatment. The reported increases in mean international normalized ratio (INR) ranged from 0.15-0.65.

CONCLUSION: The anticoagulant effect of statin initiation in patients treated with VKA is likely to be of limited clinical relevance but should be evaluated individually.

Original languageEnglish
JournalEuropean Journal of Clinical Pharmacology
Volume77
Issue number10
Pages (from-to)1435-1441
Number of pages7
ISSN0031-6970
DOIs
Publication statusPublished - Oct 2021

Bibliographical note

Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

    Research areas

  • Anticoagulants, Drug interactions, Statins, Vitamin K antagonists, Warfarin

ID: 65427173