Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist

Keld Fosgerau; Uno J Weber; Jacob W Gotfredsen; Magdalena Niepsuj Jayatissa; Carsten Leander Buus; Niels Bastian Kristensen; Mogens Vestergaard; Peter Teschendorf; Andreas Schneider; Philip Hansen; Jakob Raunsø; Lars Køber; Christian Tobias Torp-Pedersen; Charlotte Videbaek

doi:10.1186/1471-2261-10-51

Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist

Keld Fosgerau, Uno J Weber, Jacob W Gotfredsen, Magdalena Niepsuj Jayatissa, Carsten Leander Buus, Niels Bastian Kristensen, Mogens Vestergaard, Peter Teschendorf, Andreas Schneider, Philip Hansen, Jakob Raunsø, Lars Køber, Christian Tobias Torp-Pedersen, Charlotte Videbaek

46 Citations (Scopus)

Abstract

The use of mechanical/physical devices for applying mild therapeutic hypothermia is the only proven neuroprotective treatment for survivors of out of hospital cardiac arrest. However, this type of therapy is cumbersome and associated with several side-effects. We investigated the feasibility of using a transient receptor potential vanilloid type 1 (TRPV1) agonist for obtaining drug-induced sustainable mild hypothermia.

Original language	English
Journal	B M C Cardiovascular Disorders
Volume	10
Pages (from-to)	51
ISSN	1471-2261
DOIs	https://doi.org/10.1186/1471-2261-10-51
Publication status	Published - 1 Jan 2010

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Fosgerau, K., Weber, U. J., Gotfredsen, J. W., Jayatissa, M. N., Buus, C. L., Kristensen, N. B., Vestergaard, M., Teschendorf, P., Schneider, A., Hansen, P., Raunsø, J., Køber, L., Torp-Pedersen, C. T., & Videbaek, C. (2010). Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. B M C Cardiovascular Disorders, 10, 51. https://doi.org/10.1186/1471-2261-10-51

Fosgerau, K, Weber, UJ, Gotfredsen, JW, Jayatissa, MN, Buus, CL, Kristensen, NB, Vestergaard, M, Teschendorf, P, Schneider, A, Hansen, P, Raunsø, J, Køber, L , Torp-Pedersen, CT & Videbaek, C 2010, 'Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist', B M C Cardiovascular Disorders, vol. 10, pp. 51. https://doi.org/10.1186/1471-2261-10-51

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abstract = "The use of mechanical/physical devices for applying mild therapeutic hypothermia is the only proven neuroprotective treatment for survivors of out of hospital cardiac arrest. However, this type of therapy is cumbersome and associated with several side-effects. We investigated the feasibility of using a transient receptor potential vanilloid type 1 (TRPV1) agonist for obtaining drug-induced sustainable mild hypothermia.",

author = "Keld Fosgerau and Weber, \{Uno J\} and Gotfredsen, \{Jacob W\} and Jayatissa, \{Magdalena Niepsuj\} and Buus, \{Carsten Leander\} and Kristensen, \{Niels Bastian\} and Mogens Vestergaard and Peter Teschendorf and Andreas Schneider and Philip Hansen and Jakob Rauns{\o} and Lars K{\o}ber and Torp-Pedersen, \{Christian Tobias\} and Charlotte Videbaek",

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doi = "10.1186/1471-2261-10-51",

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AU - Fosgerau, Keld

AU - Weber, Uno J

AU - Gotfredsen, Jacob W

AU - Jayatissa, Magdalena Niepsuj

AU - Buus, Carsten Leander

AU - Kristensen, Niels Bastian

AU - Vestergaard, Mogens

AU - Teschendorf, Peter

AU - Schneider, Andreas

AU - Hansen, Philip

AU - Raunsø, Jakob

AU - Køber, Lars

AU - Torp-Pedersen, Christian Tobias

AU - Videbaek, Charlotte

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N2 - The use of mechanical/physical devices for applying mild therapeutic hypothermia is the only proven neuroprotective treatment for survivors of out of hospital cardiac arrest. However, this type of therapy is cumbersome and associated with several side-effects. We investigated the feasibility of using a transient receptor potential vanilloid type 1 (TRPV1) agonist for obtaining drug-induced sustainable mild hypothermia.

AB - The use of mechanical/physical devices for applying mild therapeutic hypothermia is the only proven neuroprotective treatment for survivors of out of hospital cardiac arrest. However, this type of therapy is cumbersome and associated with several side-effects. We investigated the feasibility of using a transient receptor potential vanilloid type 1 (TRPV1) agonist for obtaining drug-induced sustainable mild hypothermia.

UR - https://www.scopus.com/pages/publications/77957551184

U2 - 10.1186/1471-2261-10-51

DO - 10.1186/1471-2261-10-51

M3 - Journal article

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SN - 1471-2261

VL - 10

SP - 51

JO - B M C Cardiovascular Disorders

JF - B M C Cardiovascular Disorders

ER -

Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist

Abstract

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