Double role of mannose-binding lectin in relation to carotid intima-media thickness in patients with rheumatoid arthritis

Lone N Troelsen; Peter Garred; Buris Christiansen; Christian Torp-Pedersen; Ib J Christensen; Eva Narvestad; Søren Jacobsen

doi:10.1016/j.molimm.2009.10.021

Double role of mannose-binding lectin in relation to carotid intima-media thickness in patients with rheumatoid arthritis

Lone N Troelsen, Peter Garred, Buris Christiansen, Christian Torp-Pedersen, Ib J Christensen, Eva Narvestad, Søren Jacobsen

29 Citations (Scopus)

Abstract

Patients with rheumatoid arthritis (RA) have increased risk of atherosclerosis and cardiovascular disease (CVD) that cannot be explained by excess of traditional risk factors. Several studies indicate that mannose-binding lectin (MBL) may modify the development of atherosclerosis; both high and low serum levels of MBL are reported to be associated with CVD. Intima-media thickness of the common carotid artery (ccIMT) is a validated non-invasive anatomic measure of subclinical CVD. We examined the relation between ccIMT and MBL in 114 RA patients.

Original language	English
Journal	Molecular Immunology
Volume	47
Issue number	4
Pages (from-to)	713-8
Number of pages	6
ISSN	0161-5890
DOIs	https://doi.org/10.1016/j.molimm.2009.10.021
Publication status	Published - 1 Jan 2010

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10.1016/j.molimm.2009.10.021

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abstract = "Patients with rheumatoid arthritis (RA) have increased risk of atherosclerosis and cardiovascular disease (CVD) that cannot be explained by excess of traditional risk factors. Several studies indicate that mannose-binding lectin (MBL) may modify the development of atherosclerosis; both high and low serum levels of MBL are reported to be associated with CVD. Intima-media thickness of the common carotid artery (ccIMT) is a validated non-invasive anatomic measure of subclinical CVD. We examined the relation between ccIMT and MBL in 114 RA patients.",

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AU - Troelsen, Lone N

AU - Garred, Peter

AU - Christiansen, Buris

AU - Torp-Pedersen, Christian

AU - Christensen, Ib J

AU - Narvestad, Eva

AU - Jacobsen, Søren

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Patients with rheumatoid arthritis (RA) have increased risk of atherosclerosis and cardiovascular disease (CVD) that cannot be explained by excess of traditional risk factors. Several studies indicate that mannose-binding lectin (MBL) may modify the development of atherosclerosis; both high and low serum levels of MBL are reported to be associated with CVD. Intima-media thickness of the common carotid artery (ccIMT) is a validated non-invasive anatomic measure of subclinical CVD. We examined the relation between ccIMT and MBL in 114 RA patients.

AB - Patients with rheumatoid arthritis (RA) have increased risk of atherosclerosis and cardiovascular disease (CVD) that cannot be explained by excess of traditional risk factors. Several studies indicate that mannose-binding lectin (MBL) may modify the development of atherosclerosis; both high and low serum levels of MBL are reported to be associated with CVD. Intima-media thickness of the common carotid artery (ccIMT) is a validated non-invasive anatomic measure of subclinical CVD. We examined the relation between ccIMT and MBL in 114 RA patients.

UR - https://www.scopus.com/pages/publications/73149095157

U2 - 10.1016/j.molimm.2009.10.021

DO - 10.1016/j.molimm.2009.10.021

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JF - Molecular Immunology

IS - 4

ER -

Double role of mannose-binding lectin in relation to carotid intima-media thickness in patients with rheumatoid arthritis

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