Double-blind crossover trial of gabapentin in SPG4-linked hereditary spastic paraplegia

K H Scheuer; K Svenstrup; P Jennum; B á Rogvi-Hansen; L Werdelin; K Fenger; J E Nielsen

doi:10.1111/j.1468-1331.2007.01812.x

Double-blind crossover trial of gabapentin in SPG4-linked hereditary spastic paraplegia

K H Scheuer, K Svenstrup, P Jennum, B á Rogvi-Hansen, L Werdelin, K Fenger, J E Nielsen

Department of Clinical Neurophysiology

12 Citations (Scopus)

Abstract

Patients with hereditary spastic paraplegia (HSP) are often treated with antispastic drugs to relieve symptoms but documentation is lacking. In this study, gabapentin was tested in a double-blind crossover trial on a group of patients with HSP and linkage to the SPG4 locus. There was no difference between periods with gabapentin and placebo treatment in clinical assessment, self-reported parameters or paired transcranial magnetic stimulation evaluation of motor cortical excitability.

Original language	English
Journal	European Journal of Neurology
Volume	14
Issue number	6
Pages (from-to)	663-6
Number of pages	4
ISSN	1351-5101
DOIs	https://doi.org/10.1111/j.1468-1331.2007.01812.x
Publication status	Published - Jun 2007

Keywords

Adenosine Triphosphatases/genetics
Adult
Aged
Amines/therapeutic use
Anticonvulsants/therapeutic use
Cross-Over Studies
Cyclohexanecarboxylic Acids/therapeutic use
Double-Blind Method
Female
Gabapentin
Humans
Male
Middle Aged
Spastic Paraplegia, Hereditary/drug therapy
Spastin
Statistics, Nonparametric
gamma-Aminobutyric Acid/therapeutic use

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10.1111/j.1468-1331.2007.01812.x

Cite this

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title = "Double-blind crossover trial of gabapentin in SPG4-linked hereditary spastic paraplegia",

abstract = "Patients with hereditary spastic paraplegia (HSP) are often treated with antispastic drugs to relieve symptoms but documentation is lacking. In this study, gabapentin was tested in a double-blind crossover trial on a group of patients with HSP and linkage to the SPG4 locus. There was no difference between periods with gabapentin and placebo treatment in clinical assessment, self-reported parameters or paired transcranial magnetic stimulation evaluation of motor cortical excitability.",

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year = "2007",

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doi = "10.1111/j.1468-1331.2007.01812.x",

language = "English",

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T1 - Double-blind crossover trial of gabapentin in SPG4-linked hereditary spastic paraplegia

AU - Scheuer, K H

AU - Svenstrup, K

AU - Jennum, P

AU - Rogvi-Hansen, B á

AU - Werdelin, L

AU - Fenger, K

AU - Nielsen, J E

PY - 2007/6

Y1 - 2007/6

N2 - Patients with hereditary spastic paraplegia (HSP) are often treated with antispastic drugs to relieve symptoms but documentation is lacking. In this study, gabapentin was tested in a double-blind crossover trial on a group of patients with HSP and linkage to the SPG4 locus. There was no difference between periods with gabapentin and placebo treatment in clinical assessment, self-reported parameters or paired transcranial magnetic stimulation evaluation of motor cortical excitability.

AB - Patients with hereditary spastic paraplegia (HSP) are often treated with antispastic drugs to relieve symptoms but documentation is lacking. In this study, gabapentin was tested in a double-blind crossover trial on a group of patients with HSP and linkage to the SPG4 locus. There was no difference between periods with gabapentin and placebo treatment in clinical assessment, self-reported parameters or paired transcranial magnetic stimulation evaluation of motor cortical excitability.

KW - Adenosine Triphosphatases/genetics

KW - Adult

KW - Aged

KW - Amines/therapeutic use

KW - Anticonvulsants/therapeutic use

KW - Cross-Over Studies

KW - Cyclohexanecarboxylic Acids/therapeutic use

KW - Double-Blind Method

KW - Female

KW - Gabapentin

KW - Humans

KW - Male

KW - Middle Aged

KW - Spastic Paraplegia, Hereditary/drug therapy

KW - Spastin

KW - Statistics, Nonparametric

KW - gamma-Aminobutyric Acid/therapeutic use

UR - https://www.scopus.com/pages/publications/34249808849

U2 - 10.1111/j.1468-1331.2007.01812.x

DO - 10.1111/j.1468-1331.2007.01812.x

M3 - Journal article

C2 - 17539946

SN - 1351-5101

VL - 14

SP - 663

EP - 666

JO - European Journal of Neurology

JF - European Journal of Neurology

IS - 6

ER -

Double-blind crossover trial of gabapentin in SPG4-linked hereditary spastic paraplegia

Abstract

Keywords

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