Doses to carotid arteries after modern radiation therapy for Hodgkin lymphoma: is stroke still a late effect of treatment?

Maja V Maraldo; Nils Patrik  Brodin; Marianne C Aznar; Ivan R Vogelius; Per Munck af Rosenschöld; Peter M Petersen; Lena Specht

doi:10.1016/j.ijrobp.2013.06.004

Doses to carotid arteries after modern radiation therapy for Hodgkin lymphoma: is stroke still a late effect of treatment?

Maja V Maraldo, Nils Patrik Brodin, Marianne C Aznar, Ivan R Vogelius, Per Munck af Rosenschöld, Peter M Petersen, Lena Specht

26 Citations (Scopus)

Abstract

Hodgkin lymphoma (HL) survivors are at an increased risk of stroke because of carotid artery irradiation. However, for early-stage HL involved node radiation therapy (INRT) reduces the volume of normal tissue exposed to high doses. Here, we evaluate 3-dimensional conformal radiation therapy (3D-CRT), volumetric-modulated arc therapy (VMAT), and proton therapy (PT) delivered as INRT along with the extensive mantle field (MF) by comparing doses to the carotid arteries and corresponding risk estimates.

Original language	English
Journal	International Journal of Radiation: Oncology - Biology - Physics
Volume	87
Issue number	2
Pages (from-to)	297-303
Number of pages	7
ISSN	0360-3016
DOIs	https://doi.org/10.1016/j.ijrobp.2013.06.004
Publication status	Published - 1 Oct 2013

Keywords

Adolescent
Adult
Aged
Analysis of Variance
Antineoplastic Combined Chemotherapy Protocols
Carotid Arteries
Dose-Response Relationship, Radiation
Female
Hodgkin Disease
Humans
Male
Middle Aged
Organs at Risk
Proton Therapy
Radiotherapy Dosage
Radiotherapy, Conformal
Radiotherapy, Intensity-Modulated
Risk Assessment
Stroke
Survivors
Time Factors
Young Adult

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Maraldo, M. V., Brodin, N. P., Aznar, M. C., Vogelius, I. R., Munck af Rosenschöld, P., Petersen, P. M., & Specht, L. (2013). Doses to carotid arteries after modern radiation therapy for Hodgkin lymphoma: is stroke still a late effect of treatment? International Journal of Radiation: Oncology - Biology - Physics, 87(2), 297-303. https://doi.org/10.1016/j.ijrobp.2013.06.004

Doses to carotid arteries after modern radiation therapy for Hodgkin lymphoma: is stroke still a late effect of treatment? / Maraldo, Maja V; Brodin, Nils Patrik ; Aznar, Marianne C et al.
In: International Journal of Radiation: Oncology - Biology - Physics, Vol. 87, No. 2, 01.10.2013, p. 297-303.

Research output: Contribution to journal › Journal article › Research › peer-review

Maraldo, MV, Brodin, NP, Aznar, MC, Vogelius, IR, Munck af Rosenschöld, P, Petersen, PM & Specht, L 2013, 'Doses to carotid arteries after modern radiation therapy for Hodgkin lymphoma: is stroke still a late effect of treatment?', International Journal of Radiation: Oncology - Biology - Physics, vol. 87, no. 2, pp. 297-303. https://doi.org/10.1016/j.ijrobp.2013.06.004

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title = "Doses to carotid arteries after modern radiation therapy for Hodgkin lymphoma: is stroke still a late effect of treatment?",

abstract = "Hodgkin lymphoma (HL) survivors are at an increased risk of stroke because of carotid artery irradiation. However, for early-stage HL involved node radiation therapy (INRT) reduces the volume of normal tissue exposed to high doses. Here, we evaluate 3-dimensional conformal radiation therapy (3D-CRT), volumetric-modulated arc therapy (VMAT), and proton therapy (PT) delivered as INRT along with the extensive mantle field (MF) by comparing doses to the carotid arteries and corresponding risk estimates.",

keywords = "Adolescent, Adult, Aged, Analysis of Variance, Antineoplastic Combined Chemotherapy Protocols, Carotid Arteries, Dose-Response Relationship, Radiation, Female, Hodgkin Disease, Humans, Male, Middle Aged, Organs at Risk, Proton Therapy, Radiotherapy Dosage, Radiotherapy, Conformal, Radiotherapy, Intensity-Modulated, Risk Assessment, Stroke, Survivors, Time Factors, Young Adult",

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AU - Aznar, Marianne C

AU - Vogelius, Ivan R

AU - Munck af Rosenschöld, Per

AU - Petersen, Peter M

AU - Specht, Lena

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AB - Hodgkin lymphoma (HL) survivors are at an increased risk of stroke because of carotid artery irradiation. However, for early-stage HL involved node radiation therapy (INRT) reduces the volume of normal tissue exposed to high doses. Here, we evaluate 3-dimensional conformal radiation therapy (3D-CRT), volumetric-modulated arc therapy (VMAT), and proton therapy (PT) delivered as INRT along with the extensive mantle field (MF) by comparing doses to the carotid arteries and corresponding risk estimates.

KW - Adolescent

KW - Adult

KW - Aged

KW - Analysis of Variance

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Carotid Arteries

KW - Dose-Response Relationship, Radiation

KW - Female

KW - Hodgkin Disease

KW - Humans

KW - Male

KW - Middle Aged

KW - Organs at Risk

KW - Proton Therapy

KW - Radiotherapy Dosage

KW - Radiotherapy, Conformal

KW - Radiotherapy, Intensity-Modulated

KW - Risk Assessment

KW - Stroke

KW - Survivors

KW - Time Factors

KW - Young Adult

U2 - 10.1016/j.ijrobp.2013.06.004

DO - 10.1016/j.ijrobp.2013.06.004

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SN - 0360-3016

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SP - 297

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JO - International Journal of Radiation: Oncology - Biology - Physics

JF - International Journal of Radiation: Oncology - Biology - Physics

IS - 2

ER -

Doses to carotid arteries after modern radiation therapy for Hodgkin lymphoma: is stroke still a late effect of treatment?

Abstract

Keywords

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