Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study)

Quan Dong Nguyen; Ronald A Schachar; Chudy I Nduaka; Marvin Sperling; Anthony S Basile; Karen J Klamerus; Katherine Chi-Burris; Eric Yan; Dario A Paggiarino; Irit Rosenblatt; Roger Aitchison; Shai S Erlich; DEGAS Clinical Study Group

doi:10.1167/iovs.12-9961

Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study)

Quan Dong Nguyen, Ronald A Schachar, Chudy I Nduaka, Marvin Sperling, Anthony S Basile, Karen J Klamerus, Katherine Chi-Burris, Eric Yan, Dario A Paggiarino, Irit Rosenblatt, Roger Aitchison, Shai S Erlich, DEGAS Clinical Study Group

Department of Ophthalmology

96 Citations (Scopus)

Abstract

To evaluate the safety and efficacy of three doses of PF-04523655, a 19-nucleotide methylated double stranded siRNA targeting the RTP801 gene, for the treatment of diabetic macular edema (DME) compared to focal/grid laser photocoagulation.

Original language	English
Journal	Investigative ophthalmology & visual science
Volume	53
Issue number	12
Pages (from-to)	7666-74
Number of pages	9
ISSN	0146-0404
DOIs	https://doi.org/10.1167/iovs.12-9961
Publication status	Published - 2012

Keywords

Adult
Aged
Aged, 80 and over
Diabetic Retinopathy
Dose-Response Relationship, Drug
Double-Blind Method
Female
Follow-Up Studies
Humans
Intravitreal Injections
Macula Lutea
Macular Edema
Male
Middle Aged
Prospective Studies
RNA, Small Interfering
Tomography, Optical Coherence
Treatment Outcome
Visual Acuity

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Nguyen, Q. D., Schachar, R. A., Nduaka, C. I., Sperling, M., Basile, A. S., Klamerus, K. J., Chi-Burris, K., Yan, E., Paggiarino, D. A., Rosenblatt, I., Aitchison, R., Erlich, S. S., & DEGAS Clinical Study Group (2012). Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study). Investigative ophthalmology & visual science, 53(12), 7666-74. https://doi.org/10.1167/iovs.12-9961

Nguyen, QD, Schachar, RA, Nduaka, CI, Sperling, M, Basile, AS, Klamerus, KJ, Chi-Burris, K, Yan, E, Paggiarino, DA, Rosenblatt, I, Aitchison, R, Erlich, SS & DEGAS Clinical Study Group 2012, 'Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study)', Investigative ophthalmology & visual science, vol. 53, no. 12, pp. 7666-74. https://doi.org/10.1167/iovs.12-9961

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abstract = "To evaluate the safety and efficacy of three doses of PF-04523655, a 19-nucleotide methylated double stranded siRNA targeting the RTP801 gene, for the treatment of diabetic macular edema (DME) compared to focal/grid laser photocoagulation.",

keywords = "Adult, Aged, Aged, 80 and over, Diabetic Retinopathy, Dose-Response Relationship, Drug, Double-Blind Method, Female, Follow-Up Studies, Humans, Intravitreal Injections, Macula Lutea, Macular Edema, Male, Middle Aged, Prospective Studies, RNA, Small Interfering, Tomography, Optical Coherence, Treatment Outcome, Visual Acuity",

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AU - Sperling, Marvin

AU - Basile, Anthony S

AU - Klamerus, Karen J

AU - Chi-Burris, Katherine

AU - Yan, Eric

AU - Paggiarino, Dario A

AU - Rosenblatt, Irit

AU - Aitchison, Roger

AU - Erlich, Shai S

AU - DEGAS Clinical Study Group

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KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Intravitreal Injections

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KW - Macular Edema

KW - Male

KW - Middle Aged

KW - Prospective Studies

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KW - Tomography, Optical Coherence

KW - Treatment Outcome

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EP - 7674

JO - Investigative ophthalmology & visual science

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IS - 12

ER -

Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study)

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