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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors: a feasibility study

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  1. Residual positioning errors and uncertainties for pediatric craniospinal irradiation and the impact of image guidance

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  2. TEDDI: radiotherapy delivery in deep inspiration for pediatric patients - a NOPHO feasibility study

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  3. Dose painting based on tumor uptake of Cu-ATSM and FDG: a comparative study

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  4. A criterion for the reliable use of MRI-only radiotherapy

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Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between sub-volumes of FDG and hypoxia assessed by the uptake of 64Cu-ATSM in canine solid tumors, and evaluated the possibilities for dose redistribution within the gross tumor volume (GTV).
Original languageEnglish
JournalRadiation Oncology
Volume8
Pages (from-to)262
ISSN1748-717X
DOIs
Publication statusPublished - 2013

ID: 43157849