Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry

Torbjörn Tomson; Dina Battino; Erminio Bonizzoni; John Craig; Dick Lindhout; Anne Sabers; Emilio Perucca; Frank Vajda; EURAP Study Group

doi:10.1016/S1474-4422(11)70107-7

Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry

Torbjörn Tomson, Dina Battino, Erminio Bonizzoni, John Craig, Dick Lindhout, Anne Sabers, Emilio Perucca, Frank Vajda, EURAP Study Group

Department of Neurology

597 Citations (Scopus)

Abstract

Prenatal exposure to antiepileptic drugs is associated with a greater risk of major congenital malformations, but there is inadequate information on the comparative teratogenicity of individual antiepileptic drugs and the association with dose. We aimed to establish the risks of major congenital malformations after monotherapy exposure to four major antiepileptic drugs at different doses.

Original language	English
Journal	Lancet neurology
Volume	10
Issue number	7
Pages (from-to)	609-17
Number of pages	9
ISSN	1474-4422
DOIs	https://doi.org/10.1016/S1474-4422(11)70107-7
Publication status	Published - 2011

Keywords

Abnormalities, Drug-Induced
Anticonvulsants
Carbamazepine
Dose-Response Relationship, Drug
Epilepsy
Female
Humans
Infant
Infant, Newborn
Male
Phenobarbital
Pregnancy
Prenatal Exposure Delayed Effects
Prevalence
Prospective Studies
Registries
Triazines
Valproic Acid

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10.1016/S1474-4422(11)70107-7

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title = "Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry",

abstract = "Prenatal exposure to antiepileptic drugs is associated with a greater risk of major congenital malformations, but there is inadequate information on the comparative teratogenicity of individual antiepileptic drugs and the association with dose. We aimed to establish the risks of major congenital malformations after monotherapy exposure to four major antiepileptic drugs at different doses.",

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T1 - Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry

AU - Tomson, Torbjörn

AU - Battino, Dina

AU - Bonizzoni, Erminio

AU - Craig, John

AU - Lindhout, Dick

AU - Sabers, Anne

AU - Perucca, Emilio

AU - Vajda, Frank

AU - EURAP Study Group

PY - 2011

Y1 - 2011

N2 - Prenatal exposure to antiepileptic drugs is associated with a greater risk of major congenital malformations, but there is inadequate information on the comparative teratogenicity of individual antiepileptic drugs and the association with dose. We aimed to establish the risks of major congenital malformations after monotherapy exposure to four major antiepileptic drugs at different doses.

AB - Prenatal exposure to antiepileptic drugs is associated with a greater risk of major congenital malformations, but there is inadequate information on the comparative teratogenicity of individual antiepileptic drugs and the association with dose. We aimed to establish the risks of major congenital malformations after monotherapy exposure to four major antiepileptic drugs at different doses.

KW - Abnormalities, Drug-Induced

KW - Anticonvulsants

KW - Carbamazepine

KW - Dose-Response Relationship, Drug

KW - Epilepsy

KW - Female

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Phenobarbital

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects

KW - Prevalence

KW - Prospective Studies

KW - Registries

KW - Triazines

KW - Valproic Acid

U2 - 10.1016/S1474-4422(11)70107-7

DO - 10.1016/S1474-4422(11)70107-7

M3 - Journal article

C2 - 21652013

SN - 1474-4422

VL - 10

SP - 609

EP - 617

JO - Lancet neurology

JF - Lancet neurology

IS - 7

ER -

Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry

Abstract

Keywords

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