Dose-dependent anti-inflammatory effect of inhaled mometasone furoate/formoterol in subjects with asthma

Hendrik Nolte; Ian Pavord; Vibeke Backer; Sheldon Spector; Tulin Shekar; Davis Gates; Parameswaran Nair; Frederick Hargreave

doi:10.1016/j.rmed.2013.02.010

Dose-dependent anti-inflammatory effect of inhaled mometasone furoate/formoterol in subjects with asthma

Hendrik Nolte, Ian Pavord, Vibeke Backer, Sheldon Spector, Tulin Shekar, Davis Gates, Parameswaran Nair, Frederick Hargreave

Respiratory Medicine, Department of

30 Citations (Scopus)

Abstract

A well-controlled study in patients with allergic asthma was warranted to assess dose-dependency between fractional concentration of exhaled nitric oxide (FeNO) and sputum eosinophils to a combination of an inhaled corticosteroid plus a long-acting β2-agonist. We sought to characterize the dose-dependency of mometasone furoate/formoterol (MF/F) using FeNO and sputum eosinophil percentage as surrogates of airway inflammation in subjects with allergic asthma.

Original language	English
Journal	Respiratory medicine
Volume	107
Issue number	5
Pages (from-to)	656-64
Number of pages	9
ISSN	0954-6111
DOIs	https://doi.org/10.1016/j.rmed.2013.02.010
Publication status	Published - May 2013

Keywords

Administration, Inhalation
Adrenergic beta-2 Receptor Agonists
Adult
Asthma
Breath Tests
Bronchodilator Agents
Circadian Rhythm
Dose-Response Relationship, Drug
Double-Blind Method
Drug Combinations
Eosinophils
Ethanolamines
Female
Glucocorticoids
Humans
Leukocyte Count
Male
Middle Aged
Nitric Oxide
Peak Expiratory Flow Rate
Pregnadienediols
Sputum
Treatment Outcome
Young Adult

Access to Document

10.1016/j.rmed.2013.02.010

Cite this

@article{5c80cbfd21864c14b3975d102b7637f3,

title = "Dose-dependent anti-inflammatory effect of inhaled mometasone furoate/formoterol in subjects with asthma",

abstract = "A well-controlled study in patients with allergic asthma was warranted to assess dose-dependency between fractional concentration of exhaled nitric oxide (FeNO) and sputum eosinophils to a combination of an inhaled corticosteroid plus a long-acting β2-agonist. We sought to characterize the dose-dependency of mometasone furoate/formoterol (MF/F) using FeNO and sputum eosinophil percentage as surrogates of airway inflammation in subjects with allergic asthma.",

keywords = "Administration, Inhalation, Adrenergic beta-2 Receptor Agonists, Adult, Asthma, Breath Tests, Bronchodilator Agents, Circadian Rhythm, Dose-Response Relationship, Drug, Double-Blind Method, Drug Combinations, Eosinophils, Ethanolamines, Female, Glucocorticoids, Humans, Leukocyte Count, Male, Middle Aged, Nitric Oxide, Peak Expiratory Flow Rate, Pregnadienediols, Sputum, Treatment Outcome, Young Adult",

author = "Hendrik Nolte and Ian Pavord and Vibeke Backer and Sheldon Spector and Tulin Shekar and Davis Gates and Parameswaran Nair and Frederick Hargreave",

note = "Copyright {\textcopyright} 2013. Published by Elsevier Ltd.",

year = "2013",

month = may,

doi = "10.1016/j.rmed.2013.02.010",

language = "English",

volume = "107",

pages = "656--64",

journal = "Respiratory medicine",

issn = "0954-6111",

publisher = "W.B. Saunders Ltd",

number = "5",

}

TY - JOUR

T1 - Dose-dependent anti-inflammatory effect of inhaled mometasone furoate/formoterol in subjects with asthma

AU - Nolte, Hendrik

AU - Pavord, Ian

AU - Backer, Vibeke

AU - Spector, Sheldon

AU - Shekar, Tulin

AU - Gates, Davis

AU - Nair, Parameswaran

AU - Hargreave, Frederick

PY - 2013/5

Y1 - 2013/5

N2 - A well-controlled study in patients with allergic asthma was warranted to assess dose-dependency between fractional concentration of exhaled nitric oxide (FeNO) and sputum eosinophils to a combination of an inhaled corticosteroid plus a long-acting β2-agonist. We sought to characterize the dose-dependency of mometasone furoate/formoterol (MF/F) using FeNO and sputum eosinophil percentage as surrogates of airway inflammation in subjects with allergic asthma.

AB - A well-controlled study in patients with allergic asthma was warranted to assess dose-dependency between fractional concentration of exhaled nitric oxide (FeNO) and sputum eosinophils to a combination of an inhaled corticosteroid plus a long-acting β2-agonist. We sought to characterize the dose-dependency of mometasone furoate/formoterol (MF/F) using FeNO and sputum eosinophil percentage as surrogates of airway inflammation in subjects with allergic asthma.

KW - Administration, Inhalation

KW - Adrenergic beta-2 Receptor Agonists

KW - Adult

KW - Asthma

KW - Breath Tests

KW - Bronchodilator Agents

KW - Circadian Rhythm

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Drug Combinations

KW - Eosinophils

KW - Ethanolamines

KW - Female

KW - Glucocorticoids

KW - Humans

KW - Leukocyte Count

KW - Male

KW - Middle Aged

KW - Nitric Oxide

KW - Peak Expiratory Flow Rate

KW - Pregnadienediols

KW - Sputum

KW - Treatment Outcome

KW - Young Adult

U2 - 10.1016/j.rmed.2013.02.010

DO - 10.1016/j.rmed.2013.02.010

M3 - Journal article

C2 - 23490226

SN - 0954-6111

VL - 107

SP - 656

EP - 664

JO - Respiratory medicine

JF - Respiratory medicine

IS - 5

ER -

Dose-dependent anti-inflammatory effect of inhaled mometasone furoate/formoterol in subjects with asthma

Abstract

Keywords

Access to Document

Fingerprint

Cite this