Does lowering cholesterol have an impact on the progression of aortic stenosis?

Anders M Greve, Kristian Wachtell


    Several studies suggest that atherosclerotic disease is not a focal disease restricted to culprit lesions in the intima of the arterial wall, but seems to act as a general disease affecting the entire cardiovascular system. Evolving research has lately focused on the atherosclerotic component in calcific aortic stenosis (AS) as it seems that the valve is affected in a pattern similar to that of the vasculature. The hope is therefore, that we someday in the management of patients with calcific AS can apply some of the same treatment strategies as in atherosclerotic vascular disease. This article reviews the pathophysiological mechanisms of calcific AS, reviews current clinical trials of statin use in aortic stenosis and reports on on-going trials, evaluating whether cholesterol lowering therapy can slow disease progression in different populations. Finally, we review if computerized tomography, biomarkers, and clinical characteristics such as left ventricular ejection fraction, can be useful in stratifying patients to potential benefit of statin therapy.

    Original languageEnglish
    JournalExpert Review of Cardiovascular Therapy
    Issue number4
    Pages (from-to)277-86
    Number of pages10
    Publication statusPublished - Aug 2008


    • Aortic Valve/pathology
    • Aortic Valve Stenosis/pathology
    • Calcinosis/pathology
    • Clinical Trials as Topic
    • Endothelium, Vascular/physiopathology
    • Humans
    • Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
    • Hyperlipidemias/drug therapy
    • Risk Factors


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