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Does infliximab prevent colectomy in acute and chronic active ulcerative colitis?

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  1. Outcomes Following Pouch Formation in Paediatric Ulcerative Colitis: A Study from the Porto Group of ESPGHAN

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  2. Extraintestinal Manifestations are Associated with Disease Severity in Pediatric Onset Inflammatory Bowel Disease

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  4. Preterm Birth Has Effects on Gut Colonization in Piglets Within the First 4 Weeks of Life

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  1. Mucosal microRNAs relate to age and severity of disease in ulcerative colitis

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  2. Corrigendum to: Diagnostic Yield of Next-Generation Sequencing in Very Early-Onset Inflammatory Bowel Diseases: A Multicenter Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Outcomes Following Pouch Formation in Paediatric Ulcerative Colitis: A Study from the Porto Group of ESPGHAN

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Extraintestinal Manifestations are Associated with Disease Severity in Pediatric Onset Inflammatory Bowel Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Letter: suicide risk among adult inflammatory bowel disease patients. Authors' reply

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OBJECTIVES: The aim of the study was to evaluate clinical response, use of colectomy, and adverse events related to infliximab (IFX) treatment in acute and chronic active ulcerative colitis (UC) in children.

METHODS: Children from 3 centers, who had received IFX for UC, were identified, and patient charts were reviewed retrospectively. Data concerning symptoms, biochemistry, concomitant medical treatment, colectomy, and adverse events were registered.

RESULTS: A total of 45 patients with UC (median age at diagnosis 12 years, interquartile range 10-14) were included, and studied for a median of 15 months (interquartile range 4.5-29) after first IFX infusion. The cumulative 1- and 2-year risks of colectomy were 21% and 26%, respectively. The cumulative 1- and 2-year risks of receiving a new course of systemic corticosteroids were 32% and 48%, respectively. Twenty-one patients (46%) experienced adverse events. Most common were mild infusion reactions, but 3 (7%) had serious adverse events.

CONCLUSIONS: IFX was efficient in preventing colectomy in children with UC. The risk of receiving systemic corticosteroids was lower than that reported in other studies. Most adverse events were mild to moderate and self-limiting.

Original languageEnglish
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume58
Issue number6
Pages (from-to)768-72
Number of pages5
ISSN0277-2116
DOIs
Publication statusPublished - Jun 2014

ID: 44833021