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Does inflammation have a role in migraine?

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@article{5c905a8e4ad64ab69e3cb8a3e45f666d,
title = "Does inflammation have a role in migraine?",
abstract = "Migraine is a prevalent disorder, affecting 15.1{\%} of the world's population. In most cases, the migraine attacks are sporadic; however, some individuals experience a gradual increase in attack frequency over time, and up to 2{\%} of the general population develop chronic migraine. The mechanisms underlying this chronicity are unresolved but are hypothesized to involve a degree of inflammation. In this article, we review the relevant literature related to inflammation and migraine, from the initiation of attacks to chronification. We propose that the increase in migraine frequency leading to chronic migraine involves neurogenic neuroinflammation, possibly entailing increased expression of cytokines via activation of protein kinases in neurons and glial cells of the trigeminovascular system. We present evidence from preclinical research that supports this view and discuss the implications for migraine therapy.",
author = "Lars Edvinsson and Haanes, {Kristian Agmund} and Karin Warfvinge",
year = "2019",
month = "8",
doi = "10.1038/s41582-019-0216-y",
language = "English",
volume = "15",
pages = "483--490",
journal = "Nature Reviews Neurology",
issn = "1759-4758",
publisher = "Nature Publishing Group",
number = "8",

}

RIS

TY - JOUR

T1 - Does inflammation have a role in migraine?

AU - Edvinsson, Lars

AU - Haanes, Kristian Agmund

AU - Warfvinge, Karin

PY - 2019/8

Y1 - 2019/8

N2 - Migraine is a prevalent disorder, affecting 15.1% of the world's population. In most cases, the migraine attacks are sporadic; however, some individuals experience a gradual increase in attack frequency over time, and up to 2% of the general population develop chronic migraine. The mechanisms underlying this chronicity are unresolved but are hypothesized to involve a degree of inflammation. In this article, we review the relevant literature related to inflammation and migraine, from the initiation of attacks to chronification. We propose that the increase in migraine frequency leading to chronic migraine involves neurogenic neuroinflammation, possibly entailing increased expression of cytokines via activation of protein kinases in neurons and glial cells of the trigeminovascular system. We present evidence from preclinical research that supports this view and discuss the implications for migraine therapy.

AB - Migraine is a prevalent disorder, affecting 15.1% of the world's population. In most cases, the migraine attacks are sporadic; however, some individuals experience a gradual increase in attack frequency over time, and up to 2% of the general population develop chronic migraine. The mechanisms underlying this chronicity are unresolved but are hypothesized to involve a degree of inflammation. In this article, we review the relevant literature related to inflammation and migraine, from the initiation of attacks to chronification. We propose that the increase in migraine frequency leading to chronic migraine involves neurogenic neuroinflammation, possibly entailing increased expression of cytokines via activation of protein kinases in neurons and glial cells of the trigeminovascular system. We present evidence from preclinical research that supports this view and discuss the implications for migraine therapy.

UR - http://www.scopus.com/inward/record.url?scp=85068585771&partnerID=8YFLogxK

U2 - 10.1038/s41582-019-0216-y

DO - 10.1038/s41582-019-0216-y

M3 - Review

VL - 15

SP - 483

EP - 490

JO - Nature Reviews Neurology

JF - Nature Reviews Neurology

SN - 1759-4758

IS - 8

ER -

ID: 57526634