Abstract
The concentrations of substance P (SP) and vasoactive intestinal polypeptide (VIP) were determined in plasma in normal volunteers during acute occlusive ischaemia (n=5) and in patients with chronic ischaemia (n=5) due to obliterative arterial disease in the lower limbs. Venous SP, but not VIP, increased significantly in the early post-occlusive period in normal volunteers (P less than 0.02). In the patients no significant veno-arterial difference in plasma concentration of SP or VIP could be detected across normal or chronic ischaemic areas. The results may suggest a role for SP in the acute post-occlusive vasodilation and/or in the post-occlusive heat-pain sensation. A role for SP in chronic ischaemia could not be defined. Plasma VIP was unchanged in both acute and chronic ischaemia.
| Original language | English |
|---|---|
| Journal | Clinical physiology (Oxford, England) |
| Volume | 6 |
| Issue number | 2 |
| Pages (from-to) | 163-70 |
| Number of pages | 8 |
| ISSN | 0144-5979 |
| Publication status | Published - Apr 1986 |
Keywords
- Aged
- Arterial Occlusive Diseases
- Humans
- Ischemia
- Leg
- Middle Aged
- Substance P
- Vasoactive Intestinal Peptide
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