DNA-repair gene variants are associated with glioblastoma survival

Carl Wibom; Sara Sjöström; Roger Henriksson; Thomas Brännström; Helle Broholm; Patrik Rydén; Christoffer Johansen; Helle Collatz-Laier; Sara Hepworth; Patricia A McKinney; Lara Bethke; Richard S Houlston; Ulrika Andersson; Beatrice S Melin

doi:10.3109/0284186X.2011.616284

DNA-repair gene variants are associated with glioblastoma survival

Carl Wibom, Sara Sjöström, Roger Henriksson, Thomas Brännström, Helle Broholm, Patrik Rydén, Christoffer Johansen, Helle Collatz-Laier, Sara Hepworth, Patricia A McKinney, Lara Bethke, Richard S Houlston, Ulrika Andersson, Beatrice S Melin

Department of Pathology

13 Citations (Scopus)

Abstract

Abstract Patient outcome from glioma may be influenced by germline variation. Considering the importance of DNA repair in cancer biology as well as in response to treatment, we studied the relationship between 1458 SNPs, which captured the majority of the common genetic variation in 136 DNA repair genes, in 138 glioblastoma samples from Sweden and Denmark. We confirmed our findings in an independent cohort of 121 glioblastoma patients from the UK. Our analysis revealed nine SNPs annotating MSH2, RAD51L1 and RECQL4 that were significantly (p <0.05) associated with glioblastoma survival.

Original language	English
Journal	Acta Oncologica
Volume	51
Issue number	3
Pages (from-to)	325-332
ISSN	0284-186X
DOIs	https://doi.org/10.3109/0284186X.2011.616284
Publication status	Published - 2012

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10.3109/0284186X.2011.616284

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title = "DNA-repair gene variants are associated with glioblastoma survival",

abstract = "Abstract Patient outcome from glioma may be influenced by germline variation. Considering the importance of DNA repair in cancer biology as well as in response to treatment, we studied the relationship between 1458 SNPs, which captured the majority of the common genetic variation in 136 DNA repair genes, in 138 glioblastoma samples from Sweden and Denmark. We confirmed our findings in an independent cohort of 121 glioblastoma patients from the UK. Our analysis revealed nine SNPs annotating MSH2, RAD51L1 and RECQL4 that were significantly (p <0.05) associated with glioblastoma survival.",

author = "Carl Wibom and Sara Sj{\"o}str{\"o}m and Roger Henriksson and Thomas Br{\"a}nnstr{\"o}m and Helle Broholm and Patrik Ryd{\'e}n and Christoffer Johansen and Helle Collatz-Laier and Sara Hepworth and McKinney, \{Patricia A\} and Lara Bethke and Houlston, \{Richard S\} and Ulrika Andersson and Melin, \{Beatrice S\}",

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doi = "10.3109/0284186X.2011.616284",

language = "English",

volume = "51",

pages = "325--332",

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TY - JOUR

T1 - DNA-repair gene variants are associated with glioblastoma survival

AU - Wibom, Carl

AU - Sjöström, Sara

AU - Henriksson, Roger

AU - Brännström, Thomas

AU - Broholm, Helle

AU - Rydén, Patrik

AU - Johansen, Christoffer

AU - Collatz-Laier, Helle

AU - Hepworth, Sara

AU - McKinney, Patricia A

AU - Bethke, Lara

AU - Houlston, Richard S

AU - Andersson, Ulrika

AU - Melin, Beatrice S

PY - 2012

Y1 - 2012

N2 - Abstract Patient outcome from glioma may be influenced by germline variation. Considering the importance of DNA repair in cancer biology as well as in response to treatment, we studied the relationship between 1458 SNPs, which captured the majority of the common genetic variation in 136 DNA repair genes, in 138 glioblastoma samples from Sweden and Denmark. We confirmed our findings in an independent cohort of 121 glioblastoma patients from the UK. Our analysis revealed nine SNPs annotating MSH2, RAD51L1 and RECQL4 that were significantly (p <0.05) associated with glioblastoma survival.

AB - Abstract Patient outcome from glioma may be influenced by germline variation. Considering the importance of DNA repair in cancer biology as well as in response to treatment, we studied the relationship between 1458 SNPs, which captured the majority of the common genetic variation in 136 DNA repair genes, in 138 glioblastoma samples from Sweden and Denmark. We confirmed our findings in an independent cohort of 121 glioblastoma patients from the UK. Our analysis revealed nine SNPs annotating MSH2, RAD51L1 and RECQL4 that were significantly (p <0.05) associated with glioblastoma survival.

UR - https://www.scopus.com/pages/publications/84859753765

U2 - 10.3109/0284186X.2011.616284

DO - 10.3109/0284186X.2011.616284

M3 - Journal article

C2 - 22017238

SN - 0284-186X

VL - 51

SP - 325

EP - 332

JO - Acta Oncologica

JF - Acta Oncologica

IS - 3

ER -

DNA-repair gene variants are associated with glioblastoma survival

Abstract

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