DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

John R B Perry, Yi-Hsiang Hsu, Daniel I Chasman, Andrew D Johnson, Cathy Elks, Eva Albrecht, Irene L Andrulis, Jonathan Beesley, Gerald S Berenson, Sven Bergmann, Stig E Bojesen, Manjeet K Bolla, Judith Brown, Julie E Buring, Harry Campbell, Jenny Chang-Claude, Georgia Chenevix-Trench, Tanguy Corre, Fergus J Couch, Angela CoxKamila Czene, Adamo Pio D'adamo, Gail Davies, Ian J Deary, Joe Dennis, Douglas F Easton, Ellen G Engelhardt, Johan G Eriksson, Tõnu Esko, Peter A Fasching, Jonine D Figueroa, Henrik Flyger, Abigail Fraser, Montse Garcia-Closas, Paolo Gasparini, Christian Gieger, Graham Giles, Pascal Guenel, Sara Hägg, Per Hall, Caroline Hayward, John Hopper, Erik Ingelsson, Sharon L R Kardia, Katherine Kasiman, Julia A Knight, Jari Lahti, Debbie A Lawlor, Patrik K E Magnusson, Sara Margolin, kConFab investigators

49 Citations (Scopus)

Abstract

The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ∼50% of the variation in both age at menarche and menopause, but to date the known genes explain
Original languageEnglish
JournalHuman Molecular Genetics
Volume23
Issue number9
Pages (from-to)2490-7
Number of pages8
ISSN0964-6906
DOIs
Publication statusPublished - 8 Jan 2014

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