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DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia

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  • Magnus Borssén
  • Jessica Nordlund
  • Zahra Haider
  • Mattias Landfors
  • Pär Larsson
  • Jukka Kanerva
  • Kjeld Schmiegelow
  • Trond Flaegstad
  • Ólafur Gísli Jónsson
  • Britt-Marie Frost
  • Josefine Palle
  • Erik Forestier
  • Mats Heyman
  • Magnus Hultdin
  • Gudmar Lönnerholm
  • Sofie Degerman
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Background: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients.

Methods: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data.

Results: Among the 137 patients that later relapsed, patients with a CIMP- profile (n = 42) at initial diagnosis had an inferior overall survival (pOS5years 33%) compared to CIMP+ patients (n = 95, pOS5years 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors.

Conclusion: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.

Original languageEnglish
JournalClinical Epigenetics
Volume10
Pages (from-to)31
ISSN1868-7075
DOIs
Publication statusPublished - 2018

ID: 56423544