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Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

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Harvard

Innocenti, GM, Caminiti, R, Rouiller, EM, Knott, G, Dyrby, TB, Descoteaux, M & Thiran, J-P 2019, 'Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey' Cerebral Cortex, vol. 29, no. 2, pp. 788-801. https://doi.org/10.1093/cercor/bhx363

APA

Innocenti, G. M., Caminiti, R., Rouiller, E. M., Knott, G., Dyrby, T. B., Descoteaux, M., & Thiran, J-P. (2019). Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey. Cerebral Cortex, 29(2), 788-801. https://doi.org/10.1093/cercor/bhx363

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MLA

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Author

Innocenti, Giorgio M ; Caminiti, Roberto ; Rouiller, Eric M ; Knott, Graham ; Dyrby, Tim B ; Descoteaux, Maxime ; Thiran, Jean-Philippe. / Diversity of Cortico-descending Projections : Histological and Diffusion MRI Characterization in the Monkey. In: Cerebral Cortex. 2019 ; Vol. 29, No. 2. pp. 788-801.

Bibtex

@article{946adb92560b4b46b97ab04ee931b42d,
title = "Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey",
abstract = "The axonal composition of cortical projections originating in premotor, supplementary motor (SMA), primary motor (a4), somatosensory and parietal areas and descending towards the brain stem and spinal cord was characterized in the monkey with histological tract tracing, electron microscopy (EM) and diffusion MRI (dMRI). These 3 approaches provided complementary information. Histology provided accurate assessment of axonal diameters and size of synaptic boutons. dMRI revealed the topography of the projections (tractography), notably in the internal capsule. From measurements of axon diameters axonal conduction velocities were computed. Each area communicates with different diameter axons and this generates a hierarchy of conduction delays in this order: a4 (the shortest), SMA, premotor (F7), parietal, somatosensory, premotor F4 (the longest). We provide new interpretations for i) the well-known different anatomical and electrophysiological estimates of conduction velocity; ii) why conduction delays are probably an essential component of the cortical motor command; and iii) how histological and dMRI tractography can be integrated.",
keywords = "Journal Article, histology, corticofugal projections, conduction velocity, axon diameters, diffusion tractography",
author = "Innocenti, {Giorgio M} and Roberto Caminiti and Rouiller, {Eric M} and Graham Knott and Dyrby, {Tim B} and Maxime Descoteaux and Jean-Philippe Thiran",
year = "2019",
month = "2",
day = "1",
doi = "10.1093/cercor/bhx363",
language = "English",
volume = "29",
pages = "788--801",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Diversity of Cortico-descending Projections

T2 - Histological and Diffusion MRI Characterization in the Monkey

AU - Innocenti, Giorgio M

AU - Caminiti, Roberto

AU - Rouiller, Eric M

AU - Knott, Graham

AU - Dyrby, Tim B

AU - Descoteaux, Maxime

AU - Thiran, Jean-Philippe

PY - 2019/2/1

Y1 - 2019/2/1

N2 - The axonal composition of cortical projections originating in premotor, supplementary motor (SMA), primary motor (a4), somatosensory and parietal areas and descending towards the brain stem and spinal cord was characterized in the monkey with histological tract tracing, electron microscopy (EM) and diffusion MRI (dMRI). These 3 approaches provided complementary information. Histology provided accurate assessment of axonal diameters and size of synaptic boutons. dMRI revealed the topography of the projections (tractography), notably in the internal capsule. From measurements of axon diameters axonal conduction velocities were computed. Each area communicates with different diameter axons and this generates a hierarchy of conduction delays in this order: a4 (the shortest), SMA, premotor (F7), parietal, somatosensory, premotor F4 (the longest). We provide new interpretations for i) the well-known different anatomical and electrophysiological estimates of conduction velocity; ii) why conduction delays are probably an essential component of the cortical motor command; and iii) how histological and dMRI tractography can be integrated.

AB - The axonal composition of cortical projections originating in premotor, supplementary motor (SMA), primary motor (a4), somatosensory and parietal areas and descending towards the brain stem and spinal cord was characterized in the monkey with histological tract tracing, electron microscopy (EM) and diffusion MRI (dMRI). These 3 approaches provided complementary information. Histology provided accurate assessment of axonal diameters and size of synaptic boutons. dMRI revealed the topography of the projections (tractography), notably in the internal capsule. From measurements of axon diameters axonal conduction velocities were computed. Each area communicates with different diameter axons and this generates a hierarchy of conduction delays in this order: a4 (the shortest), SMA, premotor (F7), parietal, somatosensory, premotor F4 (the longest). We provide new interpretations for i) the well-known different anatomical and electrophysiological estimates of conduction velocity; ii) why conduction delays are probably an essential component of the cortical motor command; and iii) how histological and dMRI tractography can be integrated.

KW - Journal Article

KW - histology

KW - corticofugal projections

KW - conduction velocity

KW - axon diameters

KW - diffusion tractography

UR - http://www.scopus.com/inward/record.url?scp=85054013852&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhx363

DO - 10.1093/cercor/bhx363

M3 - Journal article

VL - 29

SP - 788

EP - 801

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 2

ER -

ID: 53366859