Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Diurnal gene expression of lipolytic natriuretic peptide receptors in white adipose tissue

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Cholecystokinin and the hormone concept

    Research output: Contribution to journalReviewpeer-review

  2. Determining minimal important change for the thyroid-related quality of life questionnaire ThyPRO

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Free testosterone and cardiometabolic parameters in men: comparison of algorithms

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The economic impact of prevention, monitoring and treatment strategies for iodine deficiency disorders in Germany

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Plasma marker for systemic inflammation is increased in Mexican Tarahumara following ultra-distance running

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Plasma volume contraction reduces atrial natriuretic peptide after four days of hypobaric hypoxia exposure

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Chromogranin A in cardiovascular endocrinology

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Bioactive adrenomedullin in plasma is associated with biventricular filling pressures in patients with advanced heart failure

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Disruption of the circadian rhythm can lead to obesity and cardiovascular disease. In white adipose tissue, activation of the natriuretic peptide receptors (NPRs) stimulates lipolysis. We have previously shown that natriuretic peptides are expressed in a circadian manner in the heart, but the temporal expression profile of their cognate receptors has not been examined in white adipose tissue. We therefore collected peri-renal white adipose tissue and serum from WT mice. Tissue mRNA contents of NPRs - NPR-A and NPR-C, the clock genes Per1 and Bmal1, and transcripts involved in lipid metabolism were quantified at 4-h intervals: in the diurnal study, mice were exposed to a period of 12 h light followed by 12 h darkness (n=52). In the circadian study, mice were kept in darkness for 24 h (n=47). Concomitant serum concentrations of free fatty acids, glycerol, triglycerides (TGs), and insulin were measured. Per1 and Bmal1 mRNA contents showed reciprocal circadian profiles (P<0.0001). NPR-A mRNA contents followed a temporal pattern (P=0.01), peaking in the dark (active) period. In contrast, NPR-C mRNA was expressed in an antiphase manner with nadir in the active period (P=0.007). TG concentrations in serum peaked in the active dark period (P=0.003). In conclusion, NPR-A and NPR-C gene expression is associated with the expression of clock genes in white adipose tissue. The reciprocal expression may thus contribute to regulate lipolysis and energy homeostasis in a diurnal manner.

Original languageEnglish
JournalEndocrine Connections
Volume4
Issue number4
Pages (from-to)206-14
Number of pages9
ISSN2049-3614
DOIs
Publication statusPublished - Dec 2015

ID: 45863663