Disturbed motilin and cholecystokinin release in the irritable bowel syndrome

K Sjölund; R Ekman; S Lindgren; J F Rehfeld

doi:10.3109/00365529609036895

Disturbed motilin and cholecystokinin release in the irritable bowel syndrome

K Sjölund, R Ekman, S Lindgren, J F Rehfeld

82 Citations (Scopus)

Abstract

BACKGROUND: The irritable bowel syndrome (IBS) is associated with motor abnormalities in the small intestine and colon. Neuropeptides may have an important role in initiating and regulating the intestinal motility. Motilin has been proposed to initiate the peristaltic reflex in the small intestine and cholecystokinin the gastrocolic reflex.

METHODS: In 18 patients with IBS and 11 healthy control subjects plasma motilin and cholecystokinin (CCK) concentrations were measured after intraluminal stimulation of water and a fat-rich meal.

RESULTS: The IBS patients had reduced motilin secretion after both water intake and the fat meal. In contrast, the fat meal elicited an exaggerated and prolonged CCK release in the IBS patients.

CONCLUSIONS: Disturbed motilin and CCK release may partly be responsible for the intestinal dysmotility in the IBS patients.

Original language	English
Journal	Scandinavian Journal of Gastroenterology
Volume	31
Issue number	11
Pages (from-to)	1110-4
Number of pages	5
ISSN	0036-5521
DOIs	https://doi.org/10.3109/00365529609036895
Publication status	Published - Nov 1996
Externally published	Yes

Keywords

Adult
Case-Control Studies
Cholecystokinin/blood
Colonic Diseases, Functional/metabolism
Dietary Fats/administration & dosage
Drinking
Female
Humans
Male
Motilin/blood
Radioimmunoassay

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10.3109/00365529609036895

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title = "Disturbed motilin and cholecystokinin release in the irritable bowel syndrome",

abstract = "BACKGROUND: The irritable bowel syndrome (IBS) is associated with motor abnormalities in the small intestine and colon. Neuropeptides may have an important role in initiating and regulating the intestinal motility. Motilin has been proposed to initiate the peristaltic reflex in the small intestine and cholecystokinin the gastrocolic reflex.METHODS: In 18 patients with IBS and 11 healthy control subjects plasma motilin and cholecystokinin (CCK) concentrations were measured after intraluminal stimulation of water and a fat-rich meal.RESULTS: The IBS patients had reduced motilin secretion after both water intake and the fat meal. In contrast, the fat meal elicited an exaggerated and prolonged CCK release in the IBS patients.CONCLUSIONS: Disturbed motilin and CCK release may partly be responsible for the intestinal dysmotility in the IBS patients.",

keywords = "Adult, Case-Control Studies, Cholecystokinin/blood, Colonic Diseases, Functional/metabolism, Dietary Fats/administration \& dosage, Drinking, Female, Humans, Male, Motilin/blood, Radioimmunoassay",

author = "K Sj{\"o}lund and R Ekman and S Lindgren and Rehfeld, \{J F\}",

year = "1996",

month = nov,

doi = "10.3109/00365529609036895",

language = "English",

volume = "31",

pages = "1110--4",

journal = "Scandinavian Journal of Gastroenterology",

issn = "0036-5521",

publisher = "Taylor and Francis Ltd.",

number = "11",

}

TY - JOUR

T1 - Disturbed motilin and cholecystokinin release in the irritable bowel syndrome

AU - Sjölund, K

AU - Ekman, R

AU - Lindgren, S

AU - Rehfeld, J F

PY - 1996/11

Y1 - 1996/11

N2 - BACKGROUND: The irritable bowel syndrome (IBS) is associated with motor abnormalities in the small intestine and colon. Neuropeptides may have an important role in initiating and regulating the intestinal motility. Motilin has been proposed to initiate the peristaltic reflex in the small intestine and cholecystokinin the gastrocolic reflex.METHODS: In 18 patients with IBS and 11 healthy control subjects plasma motilin and cholecystokinin (CCK) concentrations were measured after intraluminal stimulation of water and a fat-rich meal.RESULTS: The IBS patients had reduced motilin secretion after both water intake and the fat meal. In contrast, the fat meal elicited an exaggerated and prolonged CCK release in the IBS patients.CONCLUSIONS: Disturbed motilin and CCK release may partly be responsible for the intestinal dysmotility in the IBS patients.

AB - BACKGROUND: The irritable bowel syndrome (IBS) is associated with motor abnormalities in the small intestine and colon. Neuropeptides may have an important role in initiating and regulating the intestinal motility. Motilin has been proposed to initiate the peristaltic reflex in the small intestine and cholecystokinin the gastrocolic reflex.METHODS: In 18 patients with IBS and 11 healthy control subjects plasma motilin and cholecystokinin (CCK) concentrations were measured after intraluminal stimulation of water and a fat-rich meal.RESULTS: The IBS patients had reduced motilin secretion after both water intake and the fat meal. In contrast, the fat meal elicited an exaggerated and prolonged CCK release in the IBS patients.CONCLUSIONS: Disturbed motilin and CCK release may partly be responsible for the intestinal dysmotility in the IBS patients.

KW - Adult

KW - Case-Control Studies

KW - Cholecystokinin/blood

KW - Colonic Diseases, Functional/metabolism

KW - Dietary Fats/administration & dosage

KW - Drinking

KW - Female

KW - Humans

KW - Male

KW - Motilin/blood

KW - Radioimmunoassay

UR - https://www.scopus.com/pages/publications/0029847911

U2 - 10.3109/00365529609036895

DO - 10.3109/00365529609036895

M3 - Journal article

C2 - 8938905

SN - 0036-5521

VL - 31

SP - 1110

EP - 1114

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

IS - 11

ER -

Disturbed motilin and cholecystokinin release in the irritable bowel syndrome

Abstract

Keywords

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