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Distribution of microcrack surface density in the human otic capsule

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@article{c4216773fa6746aaa61a820097e8a4cf,
title = "Distribution of microcrack surface density in the human otic capsule",
abstract = "BACKGROUND: The bony otic capsule is comprised of highly mineralized and dense compact bone. It is rarely remodelled and degenerative changes, therefore, accumulate around the inner ear. It is also a predilection site for the pathological remodelling seen in otosclerosis. Morphometric studies have documented increased numbers of dead osteocytes and microcracks in the human otic capsule. Microcracks may disrupt the lacuno-canalicular network and cause osteocyte apoptosis ultimately breaking up the perilabyrinthine bone signalling pathways and dynamics. This may be important to understand the pathogenesis of remodelling diseases like otosclerosis.AIMS/OBJECTIVES: This study describes the spatial and regional distribution of microcrack surface density in relation to the inner ear and compares it to that previously recorded for otosclerosis.MATERIAL AND METHODS: Forty-two temporal bones and five ribs were used. All samples were undecalcified, bulk stained in basic fuchsin and plastic embedded. Unbiased stereology was used to estimate the true surface density of microcracks (mm2/mm3) in perilabyrinthine bone.RESULTS: The surface density of microcracks accumulates around the inner ear spaces, particularly in the lateral window regions, and increases with age.CONCLUSIONS AND SIGNIFICANCE: This study documents the spatial and temporal association between microfractures and otosclerosis in the otic capsule.",
keywords = "Microcracks, otosclerosis, stereology, surface density, undecalcified histology",
author = "Hansen, {Lars Juul} and Bloch, {Sune Land} and Thomas Frisch and S{\o}rensen, {Mads S{\o}lvsten}",
year = "2021",
month = jun,
doi = "10.1080/00016489.2021.1905875",
language = "English",
volume = "141",
pages = "567--571",
journal = "Acta Oto-Laryngologica",
issn = "0001-6489",
publisher = "Informa Healthcare",
number = "6",

}

RIS

TY - JOUR

T1 - Distribution of microcrack surface density in the human otic capsule

AU - Hansen, Lars Juul

AU - Bloch, Sune Land

AU - Frisch, Thomas

AU - Sørensen, Mads Sølvsten

PY - 2021/6

Y1 - 2021/6

N2 - BACKGROUND: The bony otic capsule is comprised of highly mineralized and dense compact bone. It is rarely remodelled and degenerative changes, therefore, accumulate around the inner ear. It is also a predilection site for the pathological remodelling seen in otosclerosis. Morphometric studies have documented increased numbers of dead osteocytes and microcracks in the human otic capsule. Microcracks may disrupt the lacuno-canalicular network and cause osteocyte apoptosis ultimately breaking up the perilabyrinthine bone signalling pathways and dynamics. This may be important to understand the pathogenesis of remodelling diseases like otosclerosis.AIMS/OBJECTIVES: This study describes the spatial and regional distribution of microcrack surface density in relation to the inner ear and compares it to that previously recorded for otosclerosis.MATERIAL AND METHODS: Forty-two temporal bones and five ribs were used. All samples were undecalcified, bulk stained in basic fuchsin and plastic embedded. Unbiased stereology was used to estimate the true surface density of microcracks (mm2/mm3) in perilabyrinthine bone.RESULTS: The surface density of microcracks accumulates around the inner ear spaces, particularly in the lateral window regions, and increases with age.CONCLUSIONS AND SIGNIFICANCE: This study documents the spatial and temporal association between microfractures and otosclerosis in the otic capsule.

AB - BACKGROUND: The bony otic capsule is comprised of highly mineralized and dense compact bone. It is rarely remodelled and degenerative changes, therefore, accumulate around the inner ear. It is also a predilection site for the pathological remodelling seen in otosclerosis. Morphometric studies have documented increased numbers of dead osteocytes and microcracks in the human otic capsule. Microcracks may disrupt the lacuno-canalicular network and cause osteocyte apoptosis ultimately breaking up the perilabyrinthine bone signalling pathways and dynamics. This may be important to understand the pathogenesis of remodelling diseases like otosclerosis.AIMS/OBJECTIVES: This study describes the spatial and regional distribution of microcrack surface density in relation to the inner ear and compares it to that previously recorded for otosclerosis.MATERIAL AND METHODS: Forty-two temporal bones and five ribs were used. All samples were undecalcified, bulk stained in basic fuchsin and plastic embedded. Unbiased stereology was used to estimate the true surface density of microcracks (mm2/mm3) in perilabyrinthine bone.RESULTS: The surface density of microcracks accumulates around the inner ear spaces, particularly in the lateral window regions, and increases with age.CONCLUSIONS AND SIGNIFICANCE: This study documents the spatial and temporal association between microfractures and otosclerosis in the otic capsule.

KW - Microcracks

KW - otosclerosis

KW - stereology

KW - surface density

KW - undecalcified histology

U2 - 10.1080/00016489.2021.1905875

DO - 10.1080/00016489.2021.1905875

M3 - Journal article

C2 - 33825609

VL - 141

SP - 567

EP - 571

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

SN - 0001-6489

IS - 6

ER -

ID: 65607028