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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Disease course of inflammatory bowel disease unclassified in a European population-based inception cohort - an Epi-IBD study

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  1. The epidemiology of inflammatory bowel disease: East meets West

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  2. Association of multiple patient and disease characteristics with the presence and type of pain in chronic pancreatitis

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  3. Indocyanine green retention test in cirrhosis and portal hypertension: Accuracy and relation to severity of disease

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  4. Rifaximin has minor effects on bacterial composition, inflammation and bacterial translocation in cirrhosis; A randomized trial

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  5. Aquaporin-2 Excretion in Hospitalized Patients with Cirrhosis: Relation to Development of Renal Insufficiency and Mortality

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  1. The clinical course of Crohn's disease in a Danish population-based inception cohort with more than 50 years of follow-up, 1962-2017

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  2. Correction to: The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe

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  3. The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe

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  4. Assessing aCCess to Investigations in Inflammatory Bowel Disease (ACCID): results from an international survey

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  • Epi-IBD group
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Background and Aim: A definitive diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) is not always possible, and a proportion of patients will be diagnosed as inflammatory bowel disease unclassified (IBDU). The aim of the study was to investigate the prognosis of patients initially diagnosed with IBDU and the disease course during the following 5 years. Methods: The Epi-IBD study is a prospective population-based cohort of 1289 IBD patients diagnosed in centers across Europe. Clinical data were captured prospectively throughout the follow-up period. Results: Overall, 476 (37%) patients were initially diagnosed with CD, 701 (54%) with UC, and 112 (9%) with IBDU. During follow-up, 28 (25%) IBDU patients were changed diagnoses to either UC (n = 20, 71%) or CD (n = 8, 29%) after a median of 6 months (interquartile range: 4–12), while 84 (7% of the total cohort) remained IBDU. A total of 17 (15%) IBDU patients were hospitalized for their IBD during follow-up, while 8 (7%) patients underwent surgery. Most surgeries (n = 6, 75%) were performed on patients whose diagnosis was later changed to UC; three of these colectomies led to a definitive diagnosis of UC. Most patients (n = 107, 96%) received 5-aminosalicylic acid, while 11 (10%) patients received biologicals, of whom five remained classified as IBDU. Conclusions: In a population-based inception cohort, 7% of IBD patients were not given a definitive diagnosis of IBD after 5 years of follow-up. One in four patients with IBDU eventually was classified as CD or UC. Overall, the disease course and medication burden in IBDU patients were mild.

Original languageEnglish
JournalJournal of Gastroenterology and Hepatology
Volume34
Issue number6
Pages (from-to)996-1003
Number of pages8
ISSN0815-9319
DOIs
Publication statusPublished - 2019

Bibliographical note

© 2018 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

    Research areas

  • inflammatory bowel disease unclassified, prognosis, treatment, Inflammatory Bowel Diseases/diagnosis, Prognosis, Prospective Studies, Follow-Up Studies, Humans, Middle Aged, Male, Colectomy, Colitis, Ulcerative/diagnosis, Mesalamine/therapeutic use, Disease Progression, Europe/epidemiology, Time Factors, Adult, Female, Cohort Studies

ID: 56210964