TY - JOUR
T1 - Disease burden, symptoms, and use of analgesics in patients with psoriasis with or without psoriatic arthritis
T2 - A cross-sectional study
AU - Loft, Nikolai
AU - Nguyen, Thao Thi
AU - Kristensen, Lars Erik
AU - Thyssen, Jacob P.
AU - Egeberg, Alexander
N1 - Publisher Copyright:
© 2021 American Academy of Dermatology, Inc.
PY - 2022
Y1 - 2022
N2 - BACKGROUND: Patients with psoriasis have an impaired quality of life and higher use of analgesics than the general population. Whether such use is due to skin pain or a consequence of joint pain resulting from psoriatic arthritis (PsA) is not clear.OBJECTIVES: To assess symptoms, disease burden, and use of analgesics in patients with psoriasis with and without PsA.METHOD: Symptoms, general health (EurQol 5-dimension and 5-levels), and use of analgesics were assessed in patients with psoriasis and the general population from the Danish Skin Cohort.RESULTS: We included 4016 patients with psoriasis (847 with concomitant PsA) and 3490 reference individuals. For patients with psoriasis having PsA, itch, skin pain, and/or joint pain was associated with worse general health. Use of opioids within 12 months was observed among 9.0% of the general population, 14.2% of patients with psoriasis without PsA, and 22.7% of patients with concomitant PsA. Of the symptoms, only joint pain was associated with use of analgesics (odds ratio, 3.72 (2.69-5.14); P < .0001).LIMITATIONS: Cross-sectional design.CONCLUSION: Patients with psoriasis (especially concomitant PsA) have a higher use of analgesics compared with the general population, which appears to be a result of increased joint pain.
AB - BACKGROUND: Patients with psoriasis have an impaired quality of life and higher use of analgesics than the general population. Whether such use is due to skin pain or a consequence of joint pain resulting from psoriatic arthritis (PsA) is not clear.OBJECTIVES: To assess symptoms, disease burden, and use of analgesics in patients with psoriasis with and without PsA.METHOD: Symptoms, general health (EurQol 5-dimension and 5-levels), and use of analgesics were assessed in patients with psoriasis and the general population from the Danish Skin Cohort.RESULTS: We included 4016 patients with psoriasis (847 with concomitant PsA) and 3490 reference individuals. For patients with psoriasis having PsA, itch, skin pain, and/or joint pain was associated with worse general health. Use of opioids within 12 months was observed among 9.0% of the general population, 14.2% of patients with psoriasis without PsA, and 22.7% of patients with concomitant PsA. Of the symptoms, only joint pain was associated with use of analgesics (odds ratio, 3.72 (2.69-5.14); P < .0001).LIMITATIONS: Cross-sectional design.CONCLUSION: Patients with psoriasis (especially concomitant PsA) have a higher use of analgesics compared with the general population, which appears to be a result of increased joint pain.
KW - analgesics
KW - itch
KW - opioids
KW - pain
KW - patient-reported outcomes
KW - psoriasis
KW - psoriatic arthritis
KW - quality of life
UR - http://www.scopus.com/inward/record.url?scp=85112108018&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2021.07.028
DO - 10.1016/j.jaad.2021.07.028
M3 - Journal article
C2 - 34314746
AN - SCOPUS:85112108018
SN - 0190-9622
VL - 86
SP - 590
EP - 597
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 3
ER -