Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Discrete finger sequences are widely represented in human striatum

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A meta-analysis uncovers the first sequence variant conferring risk of Bell's palsy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Developing and validating COVID-19 adverse outcome risk prediction models from a bi-national European cohort of 5594 patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Detection of biological signals from a live mammalian muscle using an early stage diamond quantum sensor

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Isolation and characterisation of novel phages infecting Lactobacillus plantarum and proposal of a new genus, "Silenusvirus"

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Development of visual attention from age 7 to age 12 in children with familial high risk for schizophrenia or bipolar disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hippocampal subfield morphology in monozygotic twins discordant for affective disorders

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A Contrast-Adaptive Method for Simultaneous Whole-Brain and Lesion Segmentation in Multiple Sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. A Bayesian reanalysis of the effects of hydroxychloroquine and azithromycin on viral carriage in patients with COVID-19

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Research in primates and rodents ascribes the striatum a critical role in integrating elementary movements into unitary action sequences through reinforcement-based learning. Yet it remains to be shown whether the human striatum represents action sequence-specific information. Young right-handed volunteers underwent functional magnetic resonance imaging while they performed four discrete finger sequences with their right hand, consisting of five button presses. Specific finger sequences could be discriminated based on the distributed activity patterns in left and right striatum, but not by average differences in single-voxel activity. Multiple bilateral clusters in putamen and caudate nucleus belonging to motor, associative, parietal and limbic territories contributed to classification sensitivity. The results show that individual finger movement sequences are widely represented in human striatum, supporting functional integration rather than segregation. The findings are compatible with the idea that the basal ganglia simultaneously integrate motor, associative and limbic aspects in the control of complex overlearned behaviour.

Original languageEnglish
Article number13189
JournalScientific Reports
Volume10
Issue number1
Pages (from-to)1-12
Number of pages12
ISSN2045-2322
DOIs
Publication statusPublished - 6 Aug 2020

ID: 60614119