Discrepant fibrinolytic response in plasma and whole blood during experimental endotoxemia in healthy volunteers

Sisse R Ostrowski; Ronan M G Berg; Nis A Windeløv; Martin A.S. Meyer; Ronni R Plovsing; Kirsten Møller; Pär I Johansson

doi:10.1371/journal.pone.0059368

Discrepant fibrinolytic response in plasma and whole blood during experimental endotoxemia in healthy volunteers

Sisse R Ostrowski, Ronan M G Berg, Nis A Windeløv, Martin A.S. Meyer, Ronni R Plovsing, Kirsten Møller, Pär I Johansson

34 Citations (Scopus)

Abstract

Sepsis induces early activation of coagulation and fibrinolysis followed by late fibrinolytic shutdown and progressive endothelial damage. The aim of the present study was to investigate and compare the functional hemostatic response in whole blood and plasma during experimental human endotoxemia by the platelet function analyzer, Multiplate and by standard and modified thrombelastography (TEG).

Original language	English
Journal	P L o S One
Volume	8
Issue number	3
Pages (from-to)	e59368
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0059368
Publication status	Published - 2013

Keywords

Blood Coagulation
Blood Platelets
Blood Pressure
Calcitonin
Endotoxemia
Erythrocytes
Fibrinogen
Humans
Lipopolysaccharides
Male
Partial Thromboplastin Time
Platelet Aggregation
Prospective Studies
Protein Precursors
Thrombelastography
Tissue Plasminogen Activator
Whole Blood Coagulation Time
Young Adult

Access to Document

10.1371/journal.pone.0059368

Cite this

@article{20872d84978e462faed2d77a7affaf44,

title = "Discrepant fibrinolytic response in plasma and whole blood during experimental endotoxemia in healthy volunteers",

abstract = "Sepsis induces early activation of coagulation and fibrinolysis followed by late fibrinolytic shutdown and progressive endothelial damage. The aim of the present study was to investigate and compare the functional hemostatic response in whole blood and plasma during experimental human endotoxemia by the platelet function analyzer, Multiplate and by standard and modified thrombelastography (TEG).",

keywords = "Blood Coagulation, Blood Platelets, Blood Pressure, Calcitonin, Endotoxemia, Erythrocytes, Fibrinogen, Humans, Lipopolysaccharides, Male, Partial Thromboplastin Time, Platelet Aggregation, Prospective Studies, Protein Precursors, Thrombelastography, Tissue Plasminogen Activator, Whole Blood Coagulation Time, Young Adult",

author = "Ostrowski, {Sisse R} and Berg, {Ronan M G} and Windel{\o}v, {Nis A} and Meyer, {Martin A.S.} and Plovsing, {Ronni R} and Kirsten M{\o}ller and Johansson, {P{\"a}r I}",

year = "2013",

doi = "10.1371/journal.pone.0059368",

language = "English",

volume = "8",

pages = "e59368",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "3",

}

TY - JOUR

T1 - Discrepant fibrinolytic response in plasma and whole blood during experimental endotoxemia in healthy volunteers

AU - Ostrowski, Sisse R

AU - Berg, Ronan M G

AU - Windeløv, Nis A

AU - Meyer, Martin A.S.

AU - Plovsing, Ronni R

AU - Møller, Kirsten

AU - Johansson, Pär I

PY - 2013

Y1 - 2013

N2 - Sepsis induces early activation of coagulation and fibrinolysis followed by late fibrinolytic shutdown and progressive endothelial damage. The aim of the present study was to investigate and compare the functional hemostatic response in whole blood and plasma during experimental human endotoxemia by the platelet function analyzer, Multiplate and by standard and modified thrombelastography (TEG).

AB - Sepsis induces early activation of coagulation and fibrinolysis followed by late fibrinolytic shutdown and progressive endothelial damage. The aim of the present study was to investigate and compare the functional hemostatic response in whole blood and plasma during experimental human endotoxemia by the platelet function analyzer, Multiplate and by standard and modified thrombelastography (TEG).

KW - Blood Coagulation

KW - Blood Platelets

KW - Blood Pressure

KW - Calcitonin

KW - Endotoxemia

KW - Erythrocytes

KW - Fibrinogen

KW - Humans

KW - Lipopolysaccharides

KW - Male

KW - Partial Thromboplastin Time

KW - Platelet Aggregation

KW - Prospective Studies

KW - Protein Precursors

KW - Thrombelastography

KW - Tissue Plasminogen Activator

KW - Whole Blood Coagulation Time

KW - Young Adult

U2 - 10.1371/journal.pone.0059368

DO - 10.1371/journal.pone.0059368

M3 - Journal article

C2 - 23555024

VL - 8

SP - e59368

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 3

ER -

Discrepant fibrinolytic response in plasma and whole blood during experimental endotoxemia in healthy volunteers

Abstract

Keywords

Access to Document

Fingerprint

Cite this