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Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

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  1. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

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  3. The genetic evolution of metastatic uveal melanoma

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  4. A catalog of genetic loci associated with kidney function from analyses of a million individuals

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  1. Socio-demographic and clinical risk factors of treatment-resistant depression: A Danish population-based cohort study

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  2. Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis

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  3. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

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  4. Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants

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  • ADHD Working Group of the Psychiatric Genomics Consortium (PGC)
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Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new information about the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes and around brain-expressed regulatory marks. Analyses of three replication studies: a cohort of individuals diagnosed with ADHD, a self-reported ADHD sample and a meta-analysis of quantitative measures of ADHD symptoms in the population, support these findings while highlighting study-specific differences on genetic overlap with educational attainment. Strong concordance with GWAS of quantitative population measures of ADHD symptoms supports that clinical diagnosis of ADHD is an extreme expression of continuous heritable traits.

Original languageEnglish
JournalNature Genetics
Volume51
Issue number1
Pages (from-to)63-75
Number of pages13
ISSN1061-4036
DOIs
Publication statusPublished - Jan 2019

ID: 56130537