Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Association between Mental Disorders and Subsequent Medical Conditions

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Restriction of non-opioid analgesics sold over-the-counter in Denmark: A national study of impact on poisonings

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Association Between Neurological Disorders and Death by Suicide in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  • ADHD Working Group of the Psychiatric Genomics Consortium (PGC)
View graph of relations

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new information about the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes and around brain-expressed regulatory marks. Analyses of three replication studies: a cohort of individuals diagnosed with ADHD, a self-reported ADHD sample and a meta-analysis of quantitative measures of ADHD symptoms in the population, support these findings while highlighting study-specific differences on genetic overlap with educational attainment. Strong concordance with GWAS of quantitative population measures of ADHD symptoms supports that clinical diagnosis of ADHD is an extreme expression of continuous heritable traits.

Original languageEnglish
JournalNature Genetics
Volume51
Issue number1
Pages (from-to)63-75
Number of pages13
ISSN1061-4036
DOIs
Publication statusPublished - Jan 2019

ID: 56130537