Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Directed connectivity between primary and premotor areas underlying ankle force control in young and older adults

Research output: Contribution to journalJournal articleResearchpeer-review

  1. On the cortical connectivity in the macaque brain: a comparison of diffusion tractography and histological tracing data

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cerebellar - premotor cortex interactions underlying visuomotor adaptation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Accurate and robust whole-head segmentation from magnetic resonance images for individualized head modeling

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Brain-informed speech separation (BISS) for enhancement of target speaker in multitalker speech perception

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Cerebellar - premotor cortex interactions underlying visuomotor adaptation

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Functional and Structural Plasticity Co-express in a Left Premotor Region During Early Bimanual Skill Learning

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Probing Context-Dependent Modulations of Ipsilateral Premotor-Motor Connectivity in Relapsing-Remitting Multiple Sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. No trace of phase: Corticomotor excitability is not tuned by phase of pericentral mu-rhythm

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The control of ankle muscle force is an integral component of walking and postural control. Aging impairs the ability to produce force steadily and accurately, which can compromise functional capacity and quality of life. Here, we hypothesized that reduced force control in older adults would be associated with altered cortico-cortical communication within a network comprising the primary motor area (M1), the premotor cortex (PMC), parietal, and prefrontal regions. We examined electroencephalographic (EEG) responses from fifteen younger (20-26 yr) and fifteen older (65-73 yr) participants during a unilateral dorsiflexion force-tracing task. Dynamic Causal Modelling (DCM) and Parametric Empirical Bayes (PEB) were used to investigate how directed connectivity between contralateral M1, PMC, parietal, and prefrontal regions was related to age group and precision in force production. DCM and PEB analyses revealed that the strength of connections between PMC and M1 were related to ankle force precision and differed by age group. For young adults, bidirectional PMC-M1 coupling was negatively related to task performance: stronger backward M1-PMC and forward PMC-M1 coupling was associated with worse force precision. The older group exhibited deviations from this pattern. For the PMC to M1 coupling, there were no age-group differences in coupling strength; however, within the older group, stronger coupling was associated with better performance. For the M1 to PMC coupling, older adults followed the same pattern as young adults - with stronger coupling accompanied by worse performance - but coupling strength was lower than in the young group. Our results suggest that bidirectional M1-PMC communication is related to precision in ankle force production and that this relationship changes with aging. We argue that the observed differences reflect compensatory reorganization that counteracts age-related sensorimotor declines and contributes to maintaining performance.

Original languageEnglish
Article number116982
JournalNeuroImage
Volume218
ISSN1053-8119
DOIs
Publication statusPublished - 1 Sep 2020

Bibliographical note

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

    Research areas

  • Aging, Connectivity, DCM, EEG

ID: 59931933