TY - JOUR
T1 - Direct intramyocardial mesenchymal stromal cell injections in patients with severe refractory angina - one year follow-up
AU - Haack-Sørensen, Mandana
AU - Friis, Tina
AU - Mathiasen, Anders B
AU - Jørgensen, Erik
AU - Hansen, Louise
AU - Dickmeiss, Ebbe
AU - Ekblond, Annette
AU - Kastrup, Jens
PY - 2013
Y1 - 2013
N2 - Aims: In patients with stable coronary artery disease (CAD) and refractory angina we performed direct intra-myocardial injections of autologous mesenchymal stromal cells (MSCs) and followed the safety and efficacy of the treatment for 12 months. Methods and Results: A total of 31 patients with stable CAD, moderate to severe angina, normal left ventricular ejection fraction and no further revascularization options, were included. Bone marrow MSCs were isolated and culture expanded for 6 - 8 weeks and then stimulated with vascular endothelial growth factor (VEGF) for one week.The 12 months follow-up demonstrated, that it was safe to culture expand MSCs and use the cells for clinical treatment. The patients maximal metabolic equivalent (MET) during exercise increased from 4.23 MET at baseline to 4.72 MET at 12 months follow-up (p
AB - Aims: In patients with stable coronary artery disease (CAD) and refractory angina we performed direct intra-myocardial injections of autologous mesenchymal stromal cells (MSCs) and followed the safety and efficacy of the treatment for 12 months. Methods and Results: A total of 31 patients with stable CAD, moderate to severe angina, normal left ventricular ejection fraction and no further revascularization options, were included. Bone marrow MSCs were isolated and culture expanded for 6 - 8 weeks and then stimulated with vascular endothelial growth factor (VEGF) for one week.The 12 months follow-up demonstrated, that it was safe to culture expand MSCs and use the cells for clinical treatment. The patients maximal metabolic equivalent (MET) during exercise increased from 4.23 MET at baseline to 4.72 MET at 12 months follow-up (p
U2 - 10.3727/096368912X636830
DO - 10.3727/096368912X636830
M3 - Journal article
C2 - 22472086
SN - 0963-6897
VL - 22
SP - 521
EP - 528
JO - Cell Transplantation
JF - Cell Transplantation
IS - 3
ER -