Direct effects of locally administered lipopolysaccharide on glucose, lipid, and protein metabolism in the placebo-controlled, bilaterally infused human leg

Mads Buhl; Ermina Bosnjak; Mikkel H Vendelbo; Jakob Gjedsted; Roni R Nielsen; Thomas K-Hafstrøm; Esben T Vestergaard; Niels Jessen; Else Tønnesen; Andreas B Møller; Steen B Pedersen; Henriette Pilegaard; Rasmus S Biensø; Jens O L Jørgensen; Niels Møller

doi:10.1210/jc.2012-3836

Direct effects of locally administered lipopolysaccharide on glucose, lipid, and protein metabolism in the placebo-controlled, bilaterally infused human leg

Mads Buhl, Ermina Bosnjak, Mikkel H Vendelbo, Jakob Gjedsted, Roni R Nielsen, Thomas K-Hafstrøm, Esben T Vestergaard, Niels Jessen, Else Tønnesen, Andreas B Møller, Steen B Pedersen, Henriette Pilegaard, Rasmus S Biensø, Jens O L Jørgensen, Niels Møller

16 Citations (Scopus)

Abstract

Accumulating evidence suggests that chronic exposure to lipopolysaccharide (LPS, endotoxin) may create a constant low-grade inflammation, leading to insulin resistance and diabetes. All previous human studies assessing the metabolic actions of LPS have used systemic administration, making discrimination between direct and indirect effects impossible.

Original language	English
Journal	The Journal of clinical endocrinology and metabolism
Volume	98
Issue number	5
Pages (from-to)	2090-9
Number of pages	10
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2012-3836
Publication status	Published - May 2013

Keywords

Adult
Biological Transport
Carbohydrate Metabolism
Glucose
Glucose Clamp Technique
Humans
Infusions, Intravenous
Insulin Resistance
Kinetics
Leg
Lipid Metabolism
Lipolysis
Lipopolysaccharides
Male
Muscle Proteins
Muscle, Skeletal
Protein Stability
Proteolysis
Radioisotope Dilution Technique
Single-Blind Method

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10.1210/jc.2012-3836

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Buhl, M., Bosnjak, E., Vendelbo, M. H., Gjedsted, J., Nielsen, R. R., K-Hafstrøm, T., Vestergaard, E. T., Jessen, N., Tønnesen, E., Møller, A. B., Pedersen, S. B., Pilegaard, H., Biensø, R. S., Jørgensen, J. O. L., & Møller, N. (2013). Direct effects of locally administered lipopolysaccharide on glucose, lipid, and protein metabolism in the placebo-controlled, bilaterally infused human leg. The Journal of clinical endocrinology and metabolism, 98(5), 2090-9. https://doi.org/10.1210/jc.2012-3836

Direct effects of locally administered lipopolysaccharide on glucose, lipid, and protein metabolism in the placebo-controlled, bilaterally infused human leg. / Buhl, Mads; Bosnjak, Ermina; Vendelbo, Mikkel H et al.

In: The Journal of clinical endocrinology and metabolism, Vol. 98, No. 5, 05.2013, p. 2090-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Buhl, M, Bosnjak, E, Vendelbo, MH, Gjedsted, J, Nielsen, RR, K-Hafstrøm, T, Vestergaard, ET, Jessen, N, Tønnesen, E, Møller, AB, Pedersen, SB, Pilegaard, H, Biensø, RS, Jørgensen, JOL & Møller, N 2013, 'Direct effects of locally administered lipopolysaccharide on glucose, lipid, and protein metabolism in the placebo-controlled, bilaterally infused human leg', The Journal of clinical endocrinology and metabolism, vol. 98, no. 5, pp. 2090-9. https://doi.org/10.1210/jc.2012-3836

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abstract = "Accumulating evidence suggests that chronic exposure to lipopolysaccharide (LPS, endotoxin) may create a constant low-grade inflammation, leading to insulin resistance and diabetes. All previous human studies assessing the metabolic actions of LPS have used systemic administration, making discrimination between direct and indirect effects impossible.",

keywords = "Adult, Biological Transport, Carbohydrate Metabolism, Glucose, Glucose Clamp Technique, Humans, Infusions, Intravenous, Insulin Resistance, Kinetics, Leg, Lipid Metabolism, Lipolysis, Lipopolysaccharides, Male, Muscle Proteins, Muscle, Skeletal, Protein Stability, Proteolysis, Radioisotope Dilution Technique, Single-Blind Method",

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AU - Buhl, Mads

AU - Bosnjak, Ermina

AU - Vendelbo, Mikkel H

AU - Gjedsted, Jakob

AU - Nielsen, Roni R

AU - K-Hafstrøm, Thomas

AU - Vestergaard, Esben T

AU - Jessen, Niels

AU - Tønnesen, Else

AU - Møller, Andreas B

AU - Pedersen, Steen B

AU - Pilegaard, Henriette

AU - Biensø, Rasmus S

AU - Jørgensen, Jens O L

AU - Møller, Niels

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N2 - Accumulating evidence suggests that chronic exposure to lipopolysaccharide (LPS, endotoxin) may create a constant low-grade inflammation, leading to insulin resistance and diabetes. All previous human studies assessing the metabolic actions of LPS have used systemic administration, making discrimination between direct and indirect effects impossible.

AB - Accumulating evidence suggests that chronic exposure to lipopolysaccharide (LPS, endotoxin) may create a constant low-grade inflammation, leading to insulin resistance and diabetes. All previous human studies assessing the metabolic actions of LPS have used systemic administration, making discrimination between direct and indirect effects impossible.

KW - Adult

KW - Biological Transport

KW - Carbohydrate Metabolism

KW - Glucose

KW - Glucose Clamp Technique

KW - Humans

KW - Infusions, Intravenous

KW - Insulin Resistance

KW - Kinetics

KW - Leg

KW - Lipid Metabolism

KW - Lipolysis

KW - Lipopolysaccharides

KW - Male

KW - Muscle Proteins

KW - Muscle, Skeletal

KW - Protein Stability

KW - Proteolysis

KW - Radioisotope Dilution Technique

KW - Single-Blind Method

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DO - 10.1210/jc.2012-3836

M3 - Journal article

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JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 5

ER -

Direct effects of locally administered lipopolysaccharide on glucose, lipid, and protein metabolism in the placebo-controlled, bilaterally infused human leg

Abstract

Keywords

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