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Direct acting antiviral treatment of chronic hepatitis C in Denmark: factors associated with and barriers to treatment initiation

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  1. Plasma calprotectin is superior to serum calprotectin as a biomarker of intestinal inflammation in ulcerative colitis

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  2. Minimally invasive assessment of hepatic function in children with indocyanine green elimination: a validation study

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  3. Long term treatment with stimulant laxatives - clinical evidence for effectiveness and safety?

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  4. Antibiotics: a risk factor for irritable bowel syndrome in a population-based cohort

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  5. Quality of life, performance status, and work capacity after post-endoscopic retrograde cholangiopancreatography pancreatitis

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  1. Incidence, prevalence and risk factors for hepatitis C in Danish prisons

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  2. Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations

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  3. Ceftriaxone-resistant Salmonella enterica serotype Typhi in a pregnant traveller returning from Karachi, Pakistan to Denmark, 2019

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  4. Establishing a hepatitis C continuum of care among HIV/hepatitis C virus-coinfected individuals in EuroSIDA

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AbstractObjectives: We describe factors associated with and barriers to initiation of Direct Acting Antiviral (DAA) treatment in patients with chronic hepatitis C, who fulfill national fibrosis treatment guidelines in Denmark.Materials and Methods: In this nationwide cohort study, we included patients with chronic hepatitis C from The Danish Database for Hepatitis B and C (DANHEP) who fulfilled fibrosis treatment criteria. Factors associated with treatment initiation and treatment failure were determined by logistic regression analyses. Medical records were reviewed from patients who fulfilled fibrosis treatment criteria, but did not initiate DAA treatment to determine the cause.Results: In 344 (49%) of 700 patients, who fulfilled treatment criteria, factors associated with DAA treatment initiation were transmission by other routes than injecting drug use odds ratio (OR) 2.13 (CI: 1.38–3.28), previous treatment failure OR 2.58 (CI: 1.84–3.61) and ALT above upper limit of normal OR 1.60 (CI: 1.18–2.17). Th...
Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Volume53
Issue number7
Pages (from-to)849-856
ISSN0036-5521
DOIs
Publication statusPublished - 1 May 2018

ID: 54945681