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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Diminished concentrations of insulin-like growth factor I in cystic fibrosis

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  1. Normal bone mineral content but unfavourable muscle/fat ratio in Klinefelter syndrome

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  2. The insulin-like growth factor axis and collagen turnover during prednisolone treatment

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  1. Growth and Adult Height in Girls With Turner Syndrome Following IGF-1 Titrated Growth Hormone Treatment

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  2. Distinguishing between hidden testes and anorchia: The role of endocrine evaluation in infancy and childhood

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  3. Heritability of pubertal timing: detailed evaluation of specific milestones in healthy boys and girls

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  4. Evaluation of Serum Insulin-like Factor 3 Quantification by LC-MS/MS as a Biomarker of Leydig Cell Function

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Cystic fibrosis is frequently accompanied by a catabolic condition with low body mass index caused by a number of disease complications. Insulin-like growth factor-I (IGF-I) is an anabolic hormone and an important marker of nutritional status, liver function, and linear growth. Available data on IGF-I in cystic fibrosis are sparse and conflicting. From 1990-3, 235 of our 240 patients (114 males, 121 females, median age 16.2 years, ranged 0.1-44.0 years) had IGF-I measured once by radioimmunoassay. IGF-I was significantly reduced compared with a healthy Scandinavian control population: mean (-2 SD to +2 SD) IGF-I SD score was -0.97 (-3.7 to 1.7) in males and -0.67 (-3.2 to 1.9) in females. Height SD score was -0.95 (-3.3 to 1.4) in males and -0.81 (-3.2 to 1.6) in females. In patients who were still in the growth period a significant correlation of IGF-I SD score to height SD score (r = 0.28, p <0.001) was found. The low IGF-I concentrations may reflect the catabolic state of many patients with cystic fibrosis and play a part in their abnormal growth pattern.
Original languageEnglish
JournalArchives of Disease in Childhood. Education and Practice Edition
Volume72
Issue number6
Pages (from-to)494-7
Number of pages4
ISSN1743-0585
Publication statusPublished - 1995

    Research areas

  • Adolescent, Adult, Age Factors, Body Height, Child, Child, Preschool, Cystic Fibrosis, Female, Humans, Infant, Insulin-Like Growth Factor I, Lung, Male, Radioimmunoassay, Reference Values, Sex Factors

ID: 36944690