Abstract
The results of studies of the effect of simethicone on abdominal gas-related symptoms have been contradictory. In a randomized, double-blind, cross-over study, ten healthy volunteers were given 30 g lactulose and 600 mg simethicone or placebo. End-expiratory breath samples were collected and analyzed for H2, and gastrointestinal symptoms registered. There were no differences in biochemical parameters or symptom score between simethicone and placebo. In contrast to previous studies, we used a sufficiently large dose of lactulose to produce gastrointestinal symptoms, a higher dose of simethicone and placebo tablets containing the same additives as the simethicone tablets. There was no demonstrable effect of simethicone on symptoms or intestinal gas production caused by carbohydrate malabsorption.
| Translated title of the contribution | Dimethicone in lactulose-induced dyspepsia. Effect on H2 production and symptoms |
|---|---|
| Original language | Danish |
| Journal | Ugeskrift for Laeger |
| Volume | 155 |
| Issue number | 42 |
| Pages (from-to) | 3378-80 |
| Number of pages | 3 |
| ISSN | 0041-5782 |
| Publication status | Published - 18 Oct 1993 |