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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA

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  1. Investigating the inflammation marker neutrophil-to-lymphocyte ratio in Danish blood donors with restless legs syndrome

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  2. Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

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  3. Dancing with atrial fibrillation - How arrhythmia affects everyday life of family members: A qualitative study

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  1. Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

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  2. Risk Factors for Being Seronegative following SARS-CoV-2 Infection in a Large Cohort of Health Care Workers in Denmark

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  3. Risk of COVID-19 in health-care workers in Denmark: an observational cohort study

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In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an important complication of malaria. The recurrence of malaria in primigravidae women irrespective of acquired protection during childhood is caused by the interaction between the parasite-expressed VAR2CSA antigen and chondroitin sulfate A (CSA) in the placental intervillous space and lack of protective antibodies. PM impairs fetal development mainly by excessive inflammation processes. After infections during pregnancy women acquire immunity to PM conferred by antibodies against VAR2CSA. Ideally, a vaccine against PM will induce antibody-mediated immune responses that block the adhesion of infected erythrocytes (IE) in the placenta.
Original languageEnglish
JournalP L o S One
Volume6
Issue number3
Pages (from-to)e17942
ISSN1932-6203
DOIs
Publication statusPublished - 1 Jan 2011

    Research areas

  • Animals, Antibodies, Protozoan, Antibody Formation, Antigens, Protozoan, Enzyme-Linked Immunosorbent Assay, Epitopes, Erythrocytes, Female, Humans, Immunoglobulin G, Malaria Vaccines, Malaria, Falciparum, Mice, Placenta, Plasmodium falciparum, Pregnancy, Protein Array Analysis, Protein Structure, Tertiary, Rabbits, Rats, Recombinant Proteins, Species Specificity

ID: 32769322