Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA

Vera V. Pinto; Sisse B. Ditlev; Kamilla E. Jensen; Mafalda Resende; Madeleine Dahlbäck; Gorm Andersen; Pernille Andersen; Thor G Theander; Ali Salanti; Morten A Nielsen

doi:10.1371/journal.pone.0017942

Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA

Vera V. Pinto, Sisse B. Ditlev, Kamilla E. Jensen, Mafalda Resende, Madeleine Dahlbäck, Gorm Andersen, Pernille Andersen, Thor G Theander, Ali Salanti, Morten A Nielsen

14 Citations (Scopus)

Abstract

In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an important complication of malaria. The recurrence of malaria in primigravidae women irrespective of acquired protection during childhood is caused by the interaction between the parasite-expressed VAR2CSA antigen and chondroitin sulfate A (CSA) in the placental intervillous space and lack of protective antibodies. PM impairs fetal development mainly by excessive inflammation processes. After infections during pregnancy women acquire immunity to PM conferred by antibodies against VAR2CSA. Ideally, a vaccine against PM will induce antibody-mediated immune responses that block the adhesion of infected erythrocytes (IE) in the placenta.

Original language	English
Journal	P L o S One
Volume	6
Issue number	3
Pages (from-to)	e17942
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0017942
Publication status	Published - 1 Jan 2011

Keywords

Animals
Antibodies, Protozoan
Antibody Formation
Antigens, Protozoan
Enzyme-Linked Immunosorbent Assay
Epitopes
Erythrocytes
Female
Humans
Immunoglobulin G
Malaria Vaccines
Malaria, Falciparum
Mice
Placenta
Plasmodium falciparum
Pregnancy
Protein Array Analysis
Protein Structure, Tertiary
Rabbits
Rats
Recombinant Proteins
Species Specificity

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title = "Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA",

abstract = "In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an important complication of malaria. The recurrence of malaria in primigravidae women irrespective of acquired protection during childhood is caused by the interaction between the parasite-expressed VAR2CSA antigen and chondroitin sulfate A (CSA) in the placental intervillous space and lack of protective antibodies. PM impairs fetal development mainly by excessive inflammation processes. After infections during pregnancy women acquire immunity to PM conferred by antibodies against VAR2CSA. Ideally, a vaccine against PM will induce antibody-mediated immune responses that block the adhesion of infected erythrocytes (IE) in the placenta.",

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author = "Pinto, \{Vera V.\} and Ditlev, \{Sisse B.\} and Jensen, \{Kamilla E.\} and Mafalda Resende and Madeleine Dahlb{\"a}ck and Gorm Andersen and Pernille Andersen and Theander, \{Thor G\} and Ali Salanti and Nielsen, \{Morten A\}",

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doi = "10.1371/journal.pone.0017942",

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T1 - Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA

AU - Pinto, Vera V.

AU - Ditlev, Sisse B.

AU - Jensen, Kamilla E.

AU - Resende, Mafalda

AU - Dahlbäck, Madeleine

AU - Andersen, Gorm

AU - Andersen, Pernille

AU - Theander, Thor G

AU - Salanti, Ali

AU - Nielsen, Morten A

PY - 2011/1/1

Y1 - 2011/1/1

N2 - In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an important complication of malaria. The recurrence of malaria in primigravidae women irrespective of acquired protection during childhood is caused by the interaction between the parasite-expressed VAR2CSA antigen and chondroitin sulfate A (CSA) in the placental intervillous space and lack of protective antibodies. PM impairs fetal development mainly by excessive inflammation processes. After infections during pregnancy women acquire immunity to PM conferred by antibodies against VAR2CSA. Ideally, a vaccine against PM will induce antibody-mediated immune responses that block the adhesion of infected erythrocytes (IE) in the placenta.

AB - In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an important complication of malaria. The recurrence of malaria in primigravidae women irrespective of acquired protection during childhood is caused by the interaction between the parasite-expressed VAR2CSA antigen and chondroitin sulfate A (CSA) in the placental intervillous space and lack of protective antibodies. PM impairs fetal development mainly by excessive inflammation processes. After infections during pregnancy women acquire immunity to PM conferred by antibodies against VAR2CSA. Ideally, a vaccine against PM will induce antibody-mediated immune responses that block the adhesion of infected erythrocytes (IE) in the placenta.

KW - Animals

KW - Antibodies, Protozoan

KW - Antibody Formation

KW - Antigens, Protozoan

KW - Enzyme-Linked Immunosorbent Assay

KW - Epitopes

KW - Erythrocytes

KW - Female

KW - Humans

KW - Immunoglobulin G

KW - Malaria Vaccines

KW - Malaria, Falciparum

KW - Mice

KW - Placenta

KW - Plasmodium falciparum

KW - Pregnancy

KW - Protein Array Analysis

KW - Protein Structure, Tertiary

KW - Rabbits

KW - Rats

KW - Recombinant Proteins

KW - Species Specificity

UR - https://www.scopus.com/pages/publications/79953051048

U2 - 10.1371/journal.pone.0017942

DO - 10.1371/journal.pone.0017942

M3 - Journal article

C2 - 21464946

SN - 1932-6203

VL - 6

SP - e17942

JO - P L o S One

JF - P L o S One

IS - 3

ER -

Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA

Abstract

Keywords

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