Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury

John O Hwabejire; Ayesha M Imam; Guang Jin; Baoling Liu; Yongqing Li; Martin Sillesen; Cecilie H Jepsen; Jennifer Lu; Marc A Demoya; Hasan B Alam

doi:10.1097/TA.0b013e31829a021a

Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury

John O Hwabejire, Ayesha M Imam, Guang Jin, Baoling Liu, Yongqing Li, Martin Sillesen, Cecilie H Jepsen, Jennifer Lu, Marc A Demoya, Hasan B Alam

Department of Anaesthesiology, Center of Head and Orthopaedic Surgery

23 Citations (Scopus)

Abstract

We have previously shown that the extent of traumatic brain injury (TBI) in large animal models can be reduced with early infusion of fresh frozen plasma (FFP), but the precise mechanisms remain unclear. In this study, we investigated whether resuscitation with FFP or normal saline differed in their effects on cerebral metabolism and excitotoxic secondary brain injury in a model of polytrauma, TBI, and hemorrhagic shock.

Original language	English
Journal	The journal of trauma and acute care surgery
Volume	75
Issue number	6
Pages (from-to)	968-75
Number of pages	8
DOIs	https://doi.org/10.1097/TA.0b013e31829a021a
Publication status	Published - Dec 2013

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Hwabejire, J. O., Imam, A. M., Jin, G., Liu, B., Li, Y., Sillesen, M., Jepsen, C. H., Lu, J., Demoya, M. A., & Alam, H. B. (2013). Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury. The journal of trauma and acute care surgery, 75(6), 968-75. https://doi.org/10.1097/TA.0b013e31829a021a

Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury. / Hwabejire, John O; Imam, Ayesha M; Jin, Guang et al.
In: The journal of trauma and acute care surgery, Vol. 75, No. 6, 12.2013, p. 968-75.

Research output: Contribution to journal › Journal article › Research › peer-review

Hwabejire, JO, Imam, AM, Jin, G, Liu, B, Li, Y, Sillesen, M, Jepsen, CH, Lu, J, Demoya, MA & Alam, HB 2013, 'Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury', The journal of trauma and acute care surgery, vol. 75, no. 6, pp. 968-75. https://doi.org/10.1097/TA.0b013e31829a021a

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AU - Liu, Baoling

AU - Li, Yongqing

AU - Sillesen, Martin

AU - Jepsen, Cecilie H

AU - Lu, Jennifer

AU - Demoya, Marc A

AU - Alam, Hasan B

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Differential effects of fresh frozen plasma and normal saline on secondary brain damage in a large animal model of polytrauma, hemorrhage and traumatic brain injury

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